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《Anhui Medical and Pharmaceutical Journal》 2007-03
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Preventive and therapeutic effects of Lycium barbarum polysaccharide on rat nonalcoholic fatty liver induced by high fat feeding

SONG Yu-lin1,ZENG Min-de2,LU Lun-gen2,FAN Zhu-ping2,MAO Yi-min2 (1.Department of Gastroenterology,The First Affiliated Hospital of Anhui Medical University,Hefei 230032;2.Renji Hospital,School of Medicine,Shanghai Jiaotong University Shanghai Institute of Digestive Disease,Shanghai 200001)  
Aim To explore the effects of lycium barbarum polysaccharide(LBP) on rat nonalcoholic fatty liver induced by high fat feeding and its possible mechanism.Methods 32 male Wistar rats were randomly divided into four groups:normal control group,model group,two doses of LBP-treated groups.The rat nonalcoholic fatty liver model was induced fed by high fat diet for 9 weeks.Serum ALT,AST,triglyceride(TG),total cholesterol(TCh),low density lipoprotein-cholesterol(LDL-ch) and high density lipoprotein-cholesterol(HDL-ch),TG,TCh,superoxidedismutase(SOD),GSH and malondialdehyde(MDA)in the liver homogenates of various treated groups were detected.Histopathological changes in the livers of various treated groups were observed.Results Compared with model group,Serum ALT level in rats treated with high dose of LBP was diminished(P0.05).Serum TCh and LDL-Ch level in the rats treated with LBP was decreased(P0.05).There was no significant difference between serum HDL-ch level in rats treated with LBP and those in model rats(P0.05).The content of TG and TCh in the liver tissue homogenates from LBP-treated rats was decreased(P0.05).The degree of hepatic steatosis and inflammation in rats treated with LBP was significantly reduced(P0.05).The decrease of the content of MDA,the increase of activities of SOD and the content of GSH in liver tissues were found in LBP-treated group(P0.05).Conclusion LBP markedly reduced rat nonalcoholic fatty liver induced by high fat feeding.The effect of LBP may be associated with the reduced levels of lipid peroxidation in liver tissues.
【CateGory Index】: R285.5
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