Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Anhui Medical and Pharmaceutical Journal》 2008-04
Add to Favorite Get Latest Update

Effects of LJTF on immunological liver injury in mice

HU Cheng-mu,JIANG Hui,LIU Hong-feng,LI Rong,LI Jun (School of Pharmacy,Anhui Medical University,Hefei 230032)  
Aim To investigate the effects of LJTF on inflammatory factors in mice with immunological liver injury.Methods The model of immunological liver injury in mice was induced by injection of Bacillus Calmette Guerin(BCG) and lipopolysaccharide(LPS) from tail vein.Indexes of liver and spleen were tested and the histopathologic change in the liver of mice was also observed.The contents of NO and iNOS in liver homogenate were assayed by spectrophotometry and the expressions of TNF-α in liver tissues were evaluated after immunohistochemistry staining.Results LJTF(100,200,400 mg·kg-1) ig ×10d could significantly decrease the raised liver and spleen indexes and also improve the aggravated liver histopathologic changes.In addition,LJTF could reduce the high levels of NO and iNOS in liver homogenate and inhibit the expression of TNF-α in liver tissue.Conclusion LJTF shows significantly protective effect on immunological liver injury in mice and the mechanism possibly is due to diminishing mediators of inflammation.
【Fund】: 安徽省高等学校青年教师科研资助计划(2003jq122)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 WANG Peng,ZHANG Nan,WANG Tao (Nursing College of Zhengzhou University,Zhengzhou,Henan 450052);Effects of thymosin on TNF-α and IL-2 in serum in mice of immunological liver injury[J];Anhui Medical and Pharmaceutical Journal;2009-08
【Citations】
Chinese Journal Full-text Database 3 Hits
1 CHEN Weigang, LI Rui, ZHOU Ting, ZHENG Yong, SUN Kan, CHANG Xiangyun, CHEN HuiDepartment of Digestive, the First Affiliated Hospital, Medical College of Shihezi University, Shihezi, Xinjiang 832008,China;Study on the Relationship between Potal Pressure and the Expression of iNOS and NO in Liver of Patients with Hepatic Cirrhosis[J];Tianjin Medical Journal;2006-04
2 WANG Hua,WEI Wei, YUE Li,WANG Ni ping ,GUI Shuang ying,WU Li,SUN Wu yi,XU Shu yun (Institute of Clinical Pharmacology , Anhui Medical University, Hefei 230032,China);Protective effect of total glucosides of paeony on immunological liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide[J];Chinese Pharmacological Bulletin;2004-08
3 Hu Chengmu,Jiang Hui,Liu Hongfeng,Li Rong,Li Jun (School of Pharmacy,Anhui Medical University,Hefei 230032);Protective effect of Lonicera japonica total flavone(LJTF) on immunological liver injury in mice[J];Pharmacology and Clinics of Chinese Materia Medica;2007-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Fang-jun1,2,WANG Jia-jia1,LI Jun1(1.Anhui Medical University,Hefei,230032;2.Anqing Medical College,Anqing,246003);Protective effect of polysaccharides from yu-ping-feng powder on immunological liver injury in mice[J];Anhui Medical and Pharmaceutical Journal;2008-04
2 SHAO Fu-rong,WEI Wei,LIU Hao,SUN Wu-yi,LI Xiang(Institute of Clinical Pharmacology of Anhui Medical University, Anhui Hefei 230032,China);Comparison of Protective Effect of Shaoqiduogan Extracted by Different Methods on Immunological Liver Injury in Mice[J];Journal of Anhui Traditional Chinese Medical College;2007-05
3 ZHU Minghui,YANG Yi,LIU Xuhua,et al The Fifth People's Hospital of Zhengzhou City,Zhengzhou 450003,China;Significance of Testing Serum Levels of IL-1β、IL-6 and TNF-α in RA Patients[J];Journal of Medical Forum;2008-18
4 Zeng Xiangfa,Zhou Zhenxiang,Huang Fang(Hubei College of Traditonal Chinese Medicine,Wuhan,Hubei,430065);The Effect of Bai Hu Shan Huang on TNF a and Liver Tissues of Hepatic Injury-suffering Rats Caused by CCI_4[J];Journal of Hubei College of Traditional Chinese Medicine;2007-04
5 ;Progress in research of the effect of Chinese herbal medicine on liver injury[J];Academic Journal of Chinese PLA Postgraduate Medical School;2009-02
6 SHI Lipu,HE Ya,ZHU Minghui,et al Department of Rheumatology and Immunology,ZhengzhouPeople’s Hospital,Zhengzhou 450003,China;Effect of Different Combination on Transaminase in Treatment of Rheumatoid Arthritis[J];Journal of Medical Forum;2009-24
7 XIAO Kun~* (Department of Clinical Medicine,Peking Union Medical College,Beijing 100730,China);Application of Total Glucosides of Peony in Autoimmune Diseases[J];Chinese Journal of Allergy and Clinical Immunology;2008-01
8 WU Li-ping,LIU Rong,BI Yu-shun,LIU Zhi-yu (Laboratory of Lymph,School of Medicine,Shandong University,Jinan 250012,China);Effect of the Fuganling granules in protecting immunity hepatic injury: a protective role[J];Journal of Shandong University(Health Sciences);2008-03
9 LIU Ming,XING Hua-yun,HAN De-wu,et al (Dept of Pathophysiology, Shanxi Medical University, Taiyuan 030001,China);Expression of nitric oxide synthase in live tissue of rats with hepatic fibrosis and hepatic cirrhosis[J];Journal of Shanxi Medical University;2007-04
10 CHEN Xia GU Jin-hua ZHU Hong-yan XU Ji-liang (Dept of Pharmacology,Medical School of Nantong University,Jiangsu Nantong 226001,China);Protective Effect of Anisodamine on Immunological Liver Injury in Mice[J];Suzhou University Journal of Medical Science;2007-06
China Proceedings of conference Full-text Database 2 Hits
1 Hu Chengmu Jiang Hui Liu Hongfeng Li Rong Li Jun (School of Pharmacy,Anhui Medical University,Hefei 230032);Protective effect of Lonicera japonica total flavone(LJTF)on immunological liver injury in mice[A];[C];2007
2 ZHOU Chun-hui (Guangdong R & D Engineering Centre for Medicine and Health Products, DongGuan, Guangdong 523762, China);A Preliminary Study on Protective Effect of Honeysuckle on Chemically Livered Injury in Mice[A];[C];2009
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 FANG Ping~1, YU Xing-zhi~2(1.Department of Infectious Diseases, Tongling People's Hospital Anhui Province ,Tongling 244000;2.Department of Infectious Diseases,The First Affiliated Hospital Of Anhui Medical University, Hefei 230022);Advances in the studies and clinical treatment on the extended spectrum beta-lactamases and AmpC beta-lactamases[J];Anhui Medical and Pharmaceutical Journal;2005-08
2 LI Gui-zhi,YANG Hui-yuan,GUO Lin-chao(Department of Infection,Anhui Provincial Corps Hospital,Chinese People~'s Armed Police Forces,Hefei 230041);Clinical observation of treatment of gravis hepatitis B with foscavir see foscarnet sodium and thymic peptide-α_1[J];Anhui Medical and Pharmaceutical Journal;2006-03
3 ZHANG Cheng-wei1,ZHOU Ya-qiu2,CHEN Lei1 (1.Anhui College of Traditional Chinese Medicine;2.Anhui Huakang Medicine Technology Development Co.Ltd.,Hefei,Anhui 230038);Advances of the hyperin pharmacology research[J];Anhui Medical and Pharmaceutical Journal;2007-11
4 CHEN Fang-jun1,2,WANG Jia-jia1,LI Jun1(1.Anhui Medical University,Hefei,230032;2.Anqing Medical College,Anqing,246003);Protective effect of polysaccharides from yu-ping-feng powder on immunological liver injury in mice[J];Anhui Medical and Pharmaceutical Journal;2008-04
5 HE Bao bin, LUO Zhong hua, LIU Jing, ZHOU Xin, HUANG Wen hua (Institude of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);The effects of compatible application of three Chinese herbal medicines on the improvement of impaired immunological function of scalded mice[J];Acta Academiae Medicine Militaris Tertiae;2001-10
6 HOU Dong-yan, HUI Rui-hua, LIOU Xiao-yuan, ZHU Yong-qiang(Department of Chemistry, Anshan Normal University, Anshan 114005), HOU Dong-yan, HUI Rui-hua,YANG Mei and TANG Rui (Department of Chemistry, Liaoning Normal University, Dalian 116029);Determination of total flavonoids and the antioxidation effect of lonicera similis hemsl[J];Analytical Laboratory;2004-11
7 SHAN Ai-lian QUAN Ju-xiang QIAN Li-qi XIAO Yong-hong (Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100083) (Department of Chinese Medicine, No.304 Hospital of The PLA, Beijing 100036);Investigation and Analysis of The Situation of Chinese Herbs Prescription in The Prevention and Treatment of Atypical Pneumoina[J];The Chinese Journal of Clinical Pharmacology;2003-04
8 ZHANG Sheng-bang1,LI Jin-yan2,GUO Yu-sheng11.College of Applied Technology of Wenzhou University,Wenzhou 325035,China2.Yuying Children's Hospital of Wenzhou Medical College,Wenzhou 325027,China;Study on Determination of Metal Elements in Honeysuckle by Carbon Pick-Up Acid Dissolvation Digestion with ICP-AES[J];Spectroscopy and Spectral Analysis;2007-06
9 Chen Baoyu Guan Qingxia Shenyang Pharmaceutical University (110016) Xuanhong medicine and pharmacy technology Co.,Ltd (300384) Chinese traditional medicine and herb of Heilongjiang University;Optimization of Extract Processing of Total Flavone in Pueraria lobata by Uniform Design[J];Heilongjiang Medicine Journal;2006-05
10 SUN De mei (Henan College of Traditional Chinese Medicine, Zhengzhou 450003, China);Study on activity of antioxidation and effect of restraining bacterium of extract components in Lonicera japonica Thunb's leaf[J];Henan Science;2002-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Chen Mingjia~*,Wu Yichun,Wu Qiang,Yang Yan, Yang Feng, Chen Minzhu(Anhui Medical College, Hefei, Anhui,230061,China; ~1Anhui Medical University, Hefei 230032,China) \;;EFFECT OF LIVER-AID TABLETS ON NF-κB EXPRESSION IN RAT HEPATIC FIBROSIS[J];Chinese Journal of Histochemistry and Cytochemistry;2005-04
2 Gao Benbo; Dai Liming; Xu Shuyun(Institute of Natural Drugs 261042);THE SCAVENGING ACTIVITIES OF TGM AND TGP ON FREE RADICALS[J];JOURNAL OF WEIFANG MEDICAL COLLEGE;1996-01
3 Wei Wei, Liang Junshan Zhou Aaiwu et al (The clinical Pharmacology Institute, Anhui Medical University, Hefei );EFFECTS OF TOTAL GLUCOSIDES OF PAEONY ON INTER-LEUKI'N 2 PRODUCTION[J];Chinese Pharmacological Bulletin;1989-03
4 DAI Li-Ming, CHEN Xue-Guang, XU Shu-Yun (Dept Of Pharmacology, Anhui Medical University, Hefei, 230032);Protective effects of total glucosides of paeony on experimental hepatitis[J];Chinese Pharmacological Bulletin;1993-06
5 ZHOU Ling Ling 1, WEI Wei, SHEN Yu Xian, XU Shu Yun (Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032) 1Dept of Pharmacology,Nanjing University of Traditional Chinese Medicine,Nanjing 210029;The effects of TGP on CJ-S_(131)-induced systemic lupus erythematosus-like model in mice[J];Chinese Pharmacological Bulletin;2002-02
6 WANG Hua,WEI Wei, YUE Li,WANG Ni ping ,GUI Shuang ying,WU Li,SUN Wu yi,XU Shu yun (Institute of Clinical Pharmacology , Anhui Medical University, Hefei 230032,China);Protective effect of total glucosides of paeony on immunological liver injury in mice induced by Bacillus Calmette-Guerin plus lipopolysaccharide[J];Chinese Pharmacological Bulletin;2004-08
7 GE Zhi-Dong; ZHOU Ai-Wu; WANG Bin et al(Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032 );Immunoregulatory effects of total glucosides of paeony (TGP),paeoniflorin (PF) and TGP removed PF on adjuvant arthritic rats[J];CHINESE PHARMACOLOGICAL BULLETIN;1995-04
8 WANG Bin, CHEN Min Zhu, XU Shu Yun (Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032);Regulatory mechanism of total glucosides of paeony on tumor necrosis factor production by peritoneal macrophages in rats[J];CHINESE PHARMACOLOGICAL BULLETIN;1997-03
9 Li Rong, Hu Chengmu, Peng Lei, et al (Dept of Pharmacy, Anhui Medical University, Hefei 230032);A orthogonal study on process for extracting total flavone of Lonicera Japonica Thunb[J];Acta Universitatis Medicinalis Anhui;2006-04
10 XU Shu-Yun;SHEN Yu-Xian;XU Du-Juan;WEI Wei;LIANG Jun-Shan(Institute of Clinical Pharmacology,Anhui Medical University),Hefei 230032;Effects of total glucosides of paeony and moutan cortex on the fonctions of pineal gland in inflammatory-immune regulation in rats[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;1994-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved