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《Anhui Medical and Pharmaceutical Journal》 2008-04
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Effects of LJTF on immunological liver injury in mice

HU Cheng-mu,JIANG Hui,LIU Hong-feng,LI Rong,LI Jun (School of Pharmacy,Anhui Medical University,Hefei 230032)  
Aim To investigate the effects of LJTF on inflammatory factors in mice with immunological liver injury.Methods The model of immunological liver injury in mice was induced by injection of Bacillus Calmette Guerin(BCG) and lipopolysaccharide(LPS) from tail vein.Indexes of liver and spleen were tested and the histopathologic change in the liver of mice was also observed.The contents of NO and iNOS in liver homogenate were assayed by spectrophotometry and the expressions of TNF-α in liver tissues were evaluated after immunohistochemistry staining.Results LJTF(100,200,400 mg·kg-1) ig ×10d could significantly decrease the raised liver and spleen indexes and also improve the aggravated liver histopathologic changes.In addition,LJTF could reduce the high levels of NO and iNOS in liver homogenate and inhibit the expression of TNF-α in liver tissue.Conclusion LJTF shows significantly protective effect on immunological liver injury in mice and the mechanism possibly is due to diminishing mediators of inflammation.
【Fund】: 安徽省高等学校青年教师科研资助计划(2003jq122)
【CateGory Index】: R285
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