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《Anhui Medical and Pharmaceutical Journal》 2008-10
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Effect of extraction from rhizoma alpiniae officinarum by CO_2 SFE on ulcer index and gastric secretion and somatostatin about stress ulcer

PENG Jun1,CAO Dian-qun2,LI Xiao-yue3(1.Department of Pathology,Anqing Affiliated Hospital of Anhui Medical University;2.Department of Pharmacology,Anqing Institute of Health Science;3.Anhui Key Laboratory of Anti-immflammatory and Immunopharmacology,Hefei 230032)  
Aim To study effect of extraction from rhizoma alpiniae officinarum by CO2 SFE(GLJ)on helcosis,gastric secretion gastrin(GAS) and somatostatin(SS) about stress ulcer.Methods Experimental gastric ulcer rats were molded by cold restraint-stress,then the effect of GLJ on ulcer index,pepsin activity,gastric secretion and SS level in gastric mucosa was observed.Results GLJ can reduce the ulcer index in stress ulcer rats,decrease the secretion of gastric mucus and pepsin activity,increase the level of SS in gastric mucosa.Conclusion It indicated that adjusting the secretion of gastric mucus,GAS and SS may be one of the mechanism of GLJ anti-ulcer.
【CateGory Index】: R285.5
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