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《Anhui Medical and Pharmaceutical Journal》 2008-12
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Protective effect of total glycosides of Zhizi on gastric mucosal lesion induced by low dose aspirin

MA Yan1,WANG Yong-zhong1,GAO Jia-rong1,ZHAO Wei-zhong2(1.Division of Pharmac,First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Hefei,Anhui 230031;2.Dept of Pharmacology,Anhui Medical University,Hefei,Anhui 230032)  
Aim To study the protective effect of total glycosides of Zhizi(TGZ) on gastric mucosal lesion induced by low dose aspirin in rats.Methods TGZ(140,70,35 mg·kg-1) and low dose aspirin(5.0 mg·kg-1,ig) were administered for a continuous 14 d.The lesion index of rats in TGZ(140,70,35 mg·kg-1) and control groups were measured.The content of nitric oxide(NO) and nitric oxide synthase(NOS) level in blood and expression of intercellular adhesion molecule(ICAM-1) were determined as well.Results Gastric mucosal lesion index of all TGZ dosage groups was obviously reduced compared with model group.Compared with model group,TGZ(140,70,35 mg·kg-1,ig,14 d)could raise NO content and NOS activity.Immunological histology examination showed that ICAM-1 expression increased evidently in model group,and TGZ could degrade the expression of ICAM-1 in gastric tissue.Conclusion TGZ can inhibit gastric mucosal lesion induced by low dose aspirin.
【Fund】: 安徽省教育厅课题 项目编号2007KJB028
【CateGory Index】: R285.5
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