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《Anhui Medical and Pharmaceutical Journal》 2009-03
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Effects of polygona-polysaccharose on blood glucose and lipid level of diabetic mice induced by alloxan

XU Mao-hong,LI Wei-ping,GONG Hui-ling(Department of Pharmacology,Anhui Medical University,Hefei 230022)  
Aim To study the effects of Polygona-polysaccharose on blood glucose and lipid level of diabetic mice induced by alloxan and to evaluate the hypoglycemic activity of polygona-polysaccharose and the mechanism.Methods Alloxan(220 mg·kg-1) was injected into its abdominal cavity to set animal model of diabetes.72 hours later,the blood samples were drawn to determine the indexes of blood glucose(FBG).After 15d administration of PSP,blood glucose was determined by blood glucose meter.Blood serum was drawn to determine TG,TC,NO,NOS and insulin.Liver and kidney were drawn to detect NO and NOS.Pancreatic pathology was studied with morphological method.Results Compared with diabetic model group,polygona-polysaccharose could decrease the blood glucose level,increase insulin,and lower NO,NOS in blood serum and liver,but it has little effect on TG and TC.Conclusion Polygona-polysaccharose could decrease blood glucose,but has little effect on TG and TC.The hypoglycemic activity of polygona-polysaccharose may be related with increasing insulin and lowering NO and NOS in blood serum and liver.
【CateGory Index】: R285.5
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