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《Anhui Medical and Pharmaceutical Journal》 2009-04
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Effect of total saponins of clematis on adjuvant arthritis in rats

XIA Lun-zhu,XU Xian-xiang,ZHANG Rui(The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Anhui,Hefei 230031)  
Aim To research effects of Total Saponins of Clematis on adjuvant arthritis in rats,and discuss its anti-inflammatory.Methods AA in rats was induced by Freund's complete adjuvant.Researched the different doses(20,50,100 mg·kg-1)effects of total saponins of clematis on primary and secondary plantar swelling,and IL-1,IL-6,IL-8,TNF-α,PGE2 of AA in rats.Results Total Saponins of Clematis at the different dose had marked effects on primary and secondary plantar swelliins,and inhibit the contents of IL-1,IL-6,IL-8,TNF-α and PGE2.Conclusion Total Saponins of Clematis had conspicuous effects on Adjuvant Arthritis in rats.
【Fund】: 国家中医药管理局中医药科学技术研究专项中药研究课题(No04-05ZP39)
【CateGory Index】: R285.5
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