Intranasal instillation of sufentanil reduces myoclonus induced by etomidate

HAN Miao-hua,WANG Hong,TONG Bin(Department of Anesthesiology,Wuhu No.1 People's Hospital,Wuhu 241000,China)  

Aim To investigate the effects of intranasal sufentanil reducing myoclonus induced by etomidate.Methods Eighty ASA class I or Ⅱ patients aged 32 to 70 years weighing 50 to 85 kg without neuromuscular dysorders who were undergoing elective surgery were randomly divided into two groups:Group A received intranasal instillation of sufentanil 0.2 μg·kg-1,which was diluted to 1 ml.Group B received intranasal instillation of normal saline l ml,After 2 min,two groups were injected etomidate 0.3 mg·kg-1.MBP,HR,SPO2 and RR were recorded before intranasal instillation of sufentanil(T0),at 1 min(T1) and 2 min(T2)after intranasal instillation of sufentanil.Myoclonus was observed and graded.Results The incidence of myoclonus was significantly lower in group A than that in group B(P0.01).There was no significant difference in MBP,HR,SPO2 and RR at all time points between group A and group B.Conclusion Intranasal instill ation of sufentanil 0.2 μg·kg-1 can reduce myoclonus induced by etomidate.

【Key Words】： sufentanil etomidate myoclonus
【CateGory Index】： R614
【DOI】： CNKI:SUN:AHYY.0.2009-04-038

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