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《Anhui Medical and Pharmaceutical Journal》 2009-06
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Protective effect of astragalus extract on acute liver injury in mice

QIU Ji1,GUI Shuang-ying2(1.Department of Pharmacy,First Renmin Hospital,Hefei 230061;2.School of Pharmacy,Anhui College of Traditional Chinese Medicine,Hefei 230031)  
Aim To explore the protective effect of astragalus extract(AE) on acute liver injury in mice.Methods A liver injury model was induced by CCl4.The of alanine aminotransferase(ALT),aspartate aminotransferase(AST) in plasma,the contents of alondiadchyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) in liver homogenate were measured.Hepatic pathological changes of liver tissue were observed.Results AE significally lowered serum ALT,AST,decreased MDA and improved SOD,GSHPx in liver homogenate as well as reduced the pathological damage on liver.Conclusion AE has protective effect on acute liver injury in mice.
【CateGory Index】: R285.5
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