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《Anhui Medical and Pharmaceutical Journal》 2009-09
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Effect of astragaloside on the disturbance of learning and memory of vascular dementia mice

YIN Yan-yan,GONG Hui-ling,LI Wei-zu(Dept of Pharmacology,Anhui Medical University,Hefei 230032)  
Aim To observe the effect and mechanism of astragaloside(AST)on the disturbance of learning and memory of vascular dementia mice.Methods The animal model of the disturbance of learning and memory of vascular dementia(VD)mice was established by three repeated times ischemia-reperfusion through the ligation of the bilateral common carotid arteries.After 14d administration of AST,t he abilities of learning and memory of mice were investigated by step-down test and step-through test in all animals.The changes of thymus index,spleen index,MDA,SOD,NO and NOS were determined.Results Compared with the sham group,the grades of learning and memory of mice in model group were lower.The AST group could increase grades of learning and memory of mice and decrease eclipse period and wrong times.There is no difference between groups.Compared with the model group,the activity of SOD was higher,while the NO,NOS and MDA increased in AST groups.Conclusion AST may have protective effect on the disturbance of learning and memory of vascular dementia mice and the mechanism might be related to its antioxidant activity.
【Fund】: 安徽省教育厅自然科学基金(NoKJ2008B301);; 安徽省高等学校青年教师科研资助项目(No2008jq1059zd)
【CateGory Index】: R285.5
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