Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Anhui Medical and Pharmaceutical Journal》 2009-12
Add to Favorite Get Latest Update

The protective effect and its mechanism of MCI-002 on focal cerebral ischemia in rats

JING Rong1,HE Guang-wei2,WU Qiang2,WANG Shan3,WU Yu-lin3,MAO Zhen-ming1 (1.School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200030;2.Hefei Industrial Pharmaceutical Institute Ltd.,Anhui Hefei 230088;3.China Pharmaceutical University,Jiangsu Nanjing 210009)  
Aim To study the protective effect and its mechanism of MCI-002,3-methoxy-4-O-(2'-methyl-3'5'6'-Trimethylpyrazine) ferulic sodium,on focal cerebral ischemia in rats.Methods Neurological behavior,the pathologic change,the cerebral water volume,the cerebral infarction rate,the cerebral biochemistry of cerebral ischemia rats such as activity of SOD,LDH,TXB2,6-Keto-PGI2 and content of MDA were evaluated using the rat model of focal cerebral ischemia.Results MCI-002 improved the neurological behavior,decreased the cerebral water volume and cerebral infarction rate,enhanced the LDH and SOD activity,lowered the MDA content,increased the 6-keto-PGF1α/TXB2 ratio,and detained the pathologic change of ischemic brain in a dose-dependent way.Conclusion MCI-002 has significantly protective effect against focal cerebral ischemia in rats,and its mechanism may be related to its improvement of energy metabolism and anti-oxidation.
【Fund】: 国家“重大新药创制”重大专项候选药物(编号:2009ZX09103-123);; 安徽省自然科学基金资助项目(070413118)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 LI Mei-xia,TIAN Guo-gang TIAN Yi, et al. (Anesthesiology of HaikouMunicpal People's Hospital ,Haikou 570208 Hainan, P. R. China);Cerebral protective effect of sodium ferulate on patients received cardiac valve disease under extracorporeal circulation[J];China Tropical Medicine;2013-06
【Citations】
Chinese Journal Full-text Database 3 Hits
1 LI Zhi-hui, TIAN Qing-wei, XING Yan, WANG Yong-ming, CHEN Jian, YE Dan-qiu(Department of Hygiene Toxicology, Tianjin Medical University, Tianjin 300070, China;;Effects of soybean isoflavones on antioxidant system in mice with cerebral ischemia reperfusion injury[J];Journal of Tianjin Medical University;2005-01
2 LIU Yun-quan, DAI YingDepartment of Anatomy, Medical College of Jinan University,Guangzhou 510632, China;Modification of the model of focal cerebral ischemia in rats with suture method[J];Chinese Journal of Clinical Anatomy;2005-02
3 REN Jun1,JIA Zhengping1,DENG Hongzhu2,HE Xiaoying1,ZHANG Ruxue1,LI Lin1(1.Department of Clinical Pharmacology,General Hospital of Lanzhou Command of People's Liberation Army,Lanzhou 730050;2. the Southern Medical University,Guangzhou 510515);Protective Effects of Ginkgolides on Three Types of Cerebral Ischemic Models in Rats[J];Traditional Chinese Drug Research & Clinical Pharmacology;2005-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Xiao-jiao,HUANG Li,JIANG Li-na,CHEN Qian-fen,ZHAO Shi-di(Department of Pathology and Pathophysiology,Bengbu Medical College,Bengbu Anhui 233030,China);Influence of genistein on spike encoding of cerebellar Purkenje cells after ischemia[J];Journal of Bengbu Medical College;2012-03
2 GAO Yongqiang,YANG Qiaolian,WANG Wei(The First Affiliated Hospital of Baotou Medical College,Baotou 014010,China);An Empirical Study on the operative Procedure of Rat Middle Cerebral Artery Occlusion Model and the Method of Drawing the material[J];Journal of Baotou Medical College;2009-04
3 WANG Guang-sheng 1,WANG Yuan-wei 2,CHEN Xiao-dong 2,GU Han-pei 1,GENG De-qin 1.1.Department of Neurology,The Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,Jiangsu,CHINA.2.Department of Neurology,the People's Hospital of Shuyang,Shuyang 223600,Jiangsu,CHINA.;Effect of Na_2 SeO_3 on behavior and infarct size after cerebral ischemia-reperfusion(IR) injury in rats[J];Hainan Medical Journal;2011-17
4 Chen Xianghong1,2),Zhang Yan2).1)The First Hospital of Zhengzhou city,Zhengzhou 450004,China;2)Department of Pharmacology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450052,China.;Influence of procyanidine on the dysmetabolism after cerebral ischemia-reperfusion in rats[J];Chinese Journal of practical Nervous Diseases;2010-22
5 PAN Jiang,ZHANG Wei,GE Wei-jun,CHEN Wu-shan,SHI Wen-ying, PAN Chun,LUO Rong(TCM University of Hunan,Changsha,Hunan 410208,China);Study on modified permanent suture for preparation of middle cerebral artery obstruction model in rats[J];Journal of Traditional Chinese Medicine University of Hunan;2011-03
6 ZHANG Juan1,LIU Bang-min1,HUANG Guo-jun2(1.Shanxi College of TCM,Xianyang 712046,China;2.Chengdu University of TCM,Chengdu 610075,China);Effects of Nao Shuantong injection on expressions of Caspase-3 and CytC after focal cerebral ischemia reperfusion in rats[J];West China Journal of Pharmaceutical Sciences;2008-06
7 CHEN Wei-song1,ZHU Xiao-gang2(1.2007 Grade of Medical Department of Graduate School;2.Department of Neurology,Cadre Wards,Jiangxi People's Hospital,Nanchang 330006,China);Research on Making Middle Cerebral Artery Occlusion Model in Rats by Using Suture Embolization Method[J];Acta Academiae Medicinae Jiangxi;2009-08
8 ZHANG Xiao-Ju, WANG Li, GAO Jian-Ying, WANG Gai-Qing, LI Guang-Lai Department of Neurology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China;Effects of Hyperlipidemia on the Expressions of MMP-9 and COX-2 in Brain Tissues of Focal Cerebral Ischemia Reperfusion Rat Model[J];Chinese Journal of Clinical Neurosciences;2011-03
9 CHEN Xiao-rui,TIAN Hui-ping,LI Jia-chuan,MENG Xian-li(Pharmacy College,Chengdu University of Traditional Chinese Medicine;The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine;State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Medicine Resources,Chengdu 610075,China);Protective effect of Tongmaixingnao dripping pills on focal cerebral ischemic damage on rats[J];Pharmacy and Clinics of Chinese Materia Medica;2011-03
10 LIU Pan-gong1,DU Yang1,ZHAO Xiao-feng2,WANG Shu2 (1.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine;Institute of Acupuncture and Moxibustion,Tianjin Key laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine,Tianjin 300193,China);The Study On Preparation of Animal Model of Cerebral Ischemic And Its Application[J];Liaoning Journal of Traditional Chinese Medicine;2010-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YANG Juan,XU Li,FANG Tai-hui(Nanjing University of TCM,Nanjing,Jiangsu 210029);Protective effects of TFE on experimental cerebral ischemia in rats[J];Anhui Medical and Pharmaceutical Journal;2009-03
2 ZHANG Xiao bing, PENG Dai yin, ZHU Man fang,ZHOU Ya Qiu, LIU Qing yun (Department of Pharmacy, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Protective Effect of Breviscapine Dropping Pill Against Focal Cerebral Ischemia Reperfusion Injury in Rats[J];Journal of Anhui Traditional Chinese Medical College;2003-01
3 Chen Xiaoxia,He Bing (Guangdong College of Pharmacy,Guangzhou,P.R.China 510224);Protective Effects of Breviscapine Against Cerebral Ischemia Reperfusion Injury in Rats[J];ACADEMIC JOURNAL OF GUANGDONG COLLEGE OF PHARMACY;1997-02
4 XIAO Xing-xian,ZHANG Yi-min(Department of Nephrology,The Second Affi liated Hospital,Sun Yat-san University,Guangzhou 510120,China);Residual renal function of patients undergoing dialysis and its protection[J];World Clinical Drugs;2009-02
5 ZHANG Qi-qi,AN Hui-xia,YANG Xia,et al(Department of Nephrology,The Second Clinical College,Harbin Medical University,Harbin 150081,China);The relationship between dyslipidemia and residue renal function in CAPD patients[J];Journal of Harbin Medical University;2009-03
6 ZHANG Qingde,QU ZhongsenDepartment of Clinical,Heze Medical College,Shandong,Heze (274030);Protective Effects of Sodium Ferulate on Diabetic Nephropaphy and its Mechanism[J];Chinese Journal of Integrated Traditional and Western Nephrology;2009-10
7 WANG Jin-zhi,HUANG Hua-yong,GUO Fu-xiao,et al.(1.Department of Chemistry,2.Department of Pharmacology,Shantou University Medical College,Shantou 515041,Guangdong,P.R.China);Protective effect of ferulic acid analogs on hypoxia-reoxygenation injury of cardiomyocyte[J];China Tropical Medicine;2011-12
8 LI Ming,LU Guo-yuan,SHEN Lei,QIAN Yong-xian(Dept of Nephrology,the First Hospital Affiliated to Suzhou University,Jiangsu Suzhou 215006,China);The Protective Effects of Sodium Ferulate on Renal Tubular Function in Chronic Renal Failure Patients[J];Suzhou University Journal of Medical Science;2008-04
9 Li Mei-xia,Tian Yi,Fu Bai-nen,Hou Chun-yan Department of Anesthesiology,Haikou Municipal People's Hospital,Haikou 570208,China;The effect of Sodium Ferulate and Trimetazidine combined pre-condition for myocardial ischemia-reperfusion injury[J];Chinese Journal of Extracorporeal Circulation;2012-03
10 LIU Yun-quan, DAI YingDepartment of Anatomy, Medical College of Jinan University,Guangzhou 510632, China;Modification of the model of focal cerebral ischemia in rats with suture method[J];Chinese Journal of Clinical Anatomy;2005-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 QI Ying-hui,QV Xiao-lu,TANG Yong-hua,DAI Qin,ZHANG Shan-bao,YAO Chun-ying.Department of Nephrology,Punan Hospital,Shanghai 200125,China;The impact of Astragalus injection on residual renal function in Hemodialysis patients[J];New Medicine;2013-02
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 ZHUANG Ying,ZHAO Hong,ZHANG Yu yuan,MA Ru lin,HAN Hui (Department of Hygiology,Bengbu Medicical College,Anhui 233003,China);Influence of soybean isoflavone on the fat level and anti-lipid peroxides in rats[J];Journal of Bengbu Medical College;2004-02
2 Ling Yihui, Huang Yiming (Department of Nutrition and Food Hygiene, Xiangya Medical School, Central-south University,Changsha 410078 China);The Effect of Soy Isoflavones on Lipoprotein Metabolism and SOD Activities of Serum in Ovariectomized Rats.[J];Practical Preventire Medicine;2002-05
3 CAO Yong jun,CHENG Yan bin (Lanzhou Medical College,Lanzhou 730000,China);THE IMPROVEMENT AND DISCUSSION OF THE MODEL OF FOCAL CEREBRAL ISCHEMIA/REPERFUSION WITH SUTURE-OCCLUDED METHOD IN RATS[J];Chinese Journal of Applied Physiology;2001-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved