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《Anhui Medical and Pharmaceutical Journal》 2010-08
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Determination of related substances of triflusal by RP-HPLC

ZHANG She-bing1,2,LIU Shi1,LU Zhou1,ZHANG Ming-ming1,DUAN Yan-bing1(1 Nanjing Hailing R&D for Chinese Traditional Medicine Pharmaceutical Technology,Nanjing 210049;2 Nanjing University of Traditional Chinese Medicine,Nanjing 210046)  
Aim To determine related substances of triflusal by RP-HPLC.Methods The analysis was performed on Diamonsil TM C18 reversed-phase analytical column(250 mm×4.6 mm,5 μm).The mobile phase consisted of a mixture of 0.1% phosphoric acid-acetonitrile(50∶50) at the flow rate of 1.0 ml·min-1.The ultraviolet detection wavelength was set at 235 nm.Results Triflusal and its related substances could be separated well.The linearity of the triflusal curve was well correlated(r=0.9999) within the range from 5.15 to 515 mg·L-1.The instrument precision RSD was 0.33%,and the detection limit was 10 ng.Conclusion The method appeared to be simple,accurate and reproducible.It can be used to control the quality of triflusal.
【CateGory Index】: R927.2
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