Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Anhui Medical and Pharmaceutical Journal》 2010-08
Add to Favorite Get Latest Update

Determination of related substances of triflusal by RP-HPLC

ZHANG She-bing1,2,LIU Shi1,LU Zhou1,ZHANG Ming-ming1,DUAN Yan-bing1(1 Nanjing Hailing R&D for Chinese Traditional Medicine Pharmaceutical Technology,Nanjing 210049;2 Nanjing University of Traditional Chinese Medicine,Nanjing 210046)  
Aim To determine related substances of triflusal by RP-HPLC.Methods The analysis was performed on Diamonsil TM C18 reversed-phase analytical column(250 mm×4.6 mm,5 μm).The mobile phase consisted of a mixture of 0.1% phosphoric acid-acetonitrile(50∶50) at the flow rate of 1.0 ml·min-1.The ultraviolet detection wavelength was set at 235 nm.Results Triflusal and its related substances could be separated well.The linearity of the triflusal curve was well correlated(r=0.9999) within the range from 5.15 to 515 mg·L-1.The instrument precision RSD was 0.33%,and the detection limit was 10 ng.Conclusion The method appeared to be simple,accurate and reproducible.It can be used to control the quality of triflusal.
【CateGory Index】: R927.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 DENG Qian,CHEN Fei-hu,WANG Qi,et al(College of Pharmacy,Anhui Medical University,Anhui 230032,China);Determination of ATPR and its related substance by HPLC[J];Anhui Medical and Pharmaceutical Journal;2011-09
2 SUN Ling-yun(Anhui Provincial Institute for Food and Drug Control,Hefei 230051,China);Determination of the related substances of Gliquidone Tablets[J];Anhui Medical and Pharmaceutical Journal;2012-01
Chinese Journal Full-text Database 1 Hits
1 ZHANG Xiao-ling1,MA Feng-yu1,ZONG Guo-jun2,GAO Song2,ZHA Da-jun2(1.Anhui College of Traditional Chinese Medicine,Hefei 230038,China;2.Hefei Xinfeng Science and Technology Development Co.,Ltd Hefei 230088,China);Determination of pirfenidone and its related substances by RP-HPLC[J];Anhui Medical and Pharmaceutical Journal;2009-11
Chinese Journal Full-text Database 2 Hits
1 HUANG Rui-hong,XIAO Da-li(Guangdong Provincial Maternal and Children Health Hospital,Guangzhou,Guangdong 510010,China);Study on quality standard of Cetirizine Hydrochloride Nasal Spray[J];Modern Medicine & Health;2009-20
2 Liu Hefeng~1,Gao Song~2(1.Department of Pharmacy,Affiliated Stomatology Hospital of Anhui Medical University,Hefei 230032,China; 2.Hefei Xinfeng Science and Technology Development Co.LTD);Determination of the Content and Related Substances Pirfenidone Tablets and its Related Substances by HPLC[J];China Pharmacist;2011-05
Chinese Journal Full-text Database 10 Hits
1 LI Wei1,CHEN Bo-lin2(1.Anhui Institute for Food and Drug Control,Hefei,Anhui 230051,China;2.Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230001,China);Determination of high molecular weight impurities in fleroxacin injection[J];Anhui Medical and Pharmaceutical Journal;2011-01
2 RUAN Jing-jing,CHEN Fei-hu,XU Jiao,SHEN Juan,SHI Jing-bo,WU Fan-rong,WANG Yuan(1.College of Pharmacy;2.Laboratory of Molecular Biology,Key Laboratory of Gene ResourceUtilization for Genetic Diseases of Ministry of Education and Anhui Province,Anhui Medical University,Hefei 230032,China);4-amino-2-trifluoromethyl-phenyl retinate induced K562 cell differentiation and cell cycle influence[J];Chinese Pharmacological Bulletin;2009-09
3 RUAN Jing-jing1,CHEN Fei-hu1,XU Jiao1,SHENG Juan1,SHI Jing-bo1,CHEN Chang-bin2,WU Fan-rong11College of Pharmacy,Anhui Medical University,Hefei 230032,Anhui,China;2Lab of Hematology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China;Preliminary study of NB4 cell differentiation induced by retinoic acid derivatives[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2008-11
4 Xie Mufeng Shanghai Institute for drug control,Shanghai 200233Luo Xiaping Shanghai Institute for drug control,Shanghai 200233Chen Yamei Shanghai Institute for drug control,Shanghai 200233;HOW TO BUILD THE METHOD OF THE RELATED SUBSTANSE ANALYSIS BY HPLC[J];Drug Stanoaros of China;2002-06
5 Xie Mu-feng(Shanghai Institute for Drug Control,Shanghai 201203);Discussion about Chromatographic Conditions and Solution Concentration in Content Determination by HPLC[J];Drug Standards of China;2008-04
6 XIE Mu-feng (Shanghai Institute for Drag Control,200233);Validation the Importance of Pharmaceutical Test of Stability of Pharmaceutical Solution[J];Chinese Journal of Pharmaceutical Analysis;2005-01
7 YANG Jing~(1a),LIU Wen-ying~(1a*),ZHANG Yi-hua~(1b),HUANG Hai-yan~2,LI Qiang~2(1a.Department of Pharmaceutical Analysis;1b.Center of Drug Discovery,China Pharmaceutical University,Nanjing 210009,China;2.Nanjing Changao Medical Science and Technology Co.Ltd,Nanjing 210007,China);Study on Determination of ZLR-8 by HPLC[J];Chinese Pharmaceutical Journal;2006-12
8 XIE Mu-feng(Shanghai Institute for Drug Control, Shanghai 200233);How to Establish A HPLC Method for Determination of Related Substances in Drugs[J];Chinese Journal of Pharmaceuticals;2007-01
9 ZHANG Fei,LI Xiao-min,XU Xiang-yang,LUO Hong-peng(Jiangsu Simcere Pharmaceutical Research Company LTD.,Nanjing 210042,China);HPLC determination of the concentrations of mitiglinide and its related substances[J];Chinese Journal of New Drugs;2007-06
10 SHEN Juan,SHI Jing-bo,CHEN Fei-hu,RUAN Jing-jing,WANG Lu,WU Fan-rong(College of Pharmacy,Anhui Medical University,Anhui,200032,China);Synthesis and anti-tumor activity of retinoic acid derivatives[J];Chinese Journal of New Drugs;2009-11
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 Sun Jian-he,Shi Qi-de,Wang Ru(Lu'nan Pharmaceutical Share Limited Corporation,Linyi,276005);Determination of Cetirizine hydrochloride Tablets by HPLC[J];Shangdong Pharmaceutical Industry;2004-07
2 Yao Qiuyan,Ren Bin,Li Minwei,Huang Biying,Cheng Junyuan, Deng Bin(The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080);Determination of cetirizine hydrochloride in tablets by HPLC[J];Tianjin Pharmacy;2006-01
3 WANG Yong-sheng,ZHAO Xiao-ping,ZHONG Jiao,CHEN Yan,LIU Xiao-quan,WANG Guang-jiCenter of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,China;Determination of pirfenidone in Beagle dog′s plasma by HPLC-UV and study of its pharmacokinetics[J];Journal of China Pharmaceutical University;2006-02
4 MA Zhen, WANG Zun-Yuan, SHEN Zheng-Rong (Institute of Materia Medica, Zhejiang A cademy of Medical. Sciences, Hangzhou 310013);Synthesis of Pirfenidone[J];Chinese Journal of Pharmaceuticals;2006-06
5 XUE Ke-ying 1, ZHANG Hao 2, CHEN Yan 1(1 Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science andTechnology, Wuhan 430022,China; 2 School of Medicine, Jiujiang Medical College,Jiujiang 332000,China);A new antifibrotic tissue growth antagonist:pirfenidone[J];Chinese New Drugs Journal;2005-08
6 Zhang Jipan , Shi Jingping, Su Chengxia, Zong Yanyan, Duan Xiaohan ( Yangtza River Pharmacy Group, Jiangsu, Taizhou 225321 P. R. China; Anhui College of TCM);Comparative Study on Determination the Content of Cetirizine Hydrochloride Tablets by RP-HPLC and UY Spectrophotometry[J];China Pharmacist;2006-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved