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《Anhui Medical and Pharmaceutical Journal》 2011-03
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Significance of IL-17 and hs-CRP detected in patients with acute aoronary syndrome

WEI De-yu1,DING Xiao-mei1,2,SU Hao1,2,HU Hao1,2,CHEN Dong1(1.Department of Cardiology,Anhui Provincial Hospital Affiliated to Anhui Medical University;2.Institute of Cardiovascular Research,Hefei,Anhui 230001,China)  
Aim To observe the changes of IL-17 and hs-CRP in patients with acute coronary syndrome(ACS),and whether there was correlation between the two or not,and to investigate the relationship between IL-17 and the instability of plaque.Methods 113 patients were divided into 4 groups:40 cases with acute myocardial infarction(AMI),31 cases with unstable angina(UA),18 patients with stable angina pectoris(SAP),and 24 patients with chest pain syndrome(CPS).All were taken blood from immediately after admission in,and centrifugal samples stored in-80℃ refrigerator to detect the serum levels of IL-17,hs-CRP,cTNI,CK-MB by ELISA.Results AMI and UA in peripheral blood levels of IL-17 [(37.04 ± 9.92),(30.11 ± 5.67) ng·L-1] were significantly higher than the SAP(20.95 ± 5.08) ng·L-1 and the CPS(15.81 ± 7.65) ng·L-1(P0.01).Levels of hs-CRP in AMI and UA[(39.21 ± 14.42),(11.57 ± 3.71) mg·L-1],were significantly higher than the SAP(3.53 ± 4.45) mg·L-1 and the CPS gr(2.94 ±3.97)mg·L-1(P0.05).IL-17 and hs-CRP were positively correlated(r=0.364,P0.001).Conclusion The serum levels of IL-17 were significantly increased and was positively correlated with hs-CRP.We suggested that IL-17 becorrelated with the instability of atherosclerotic plaque,and also involved in the pathogenesis of ACS.
【CateGory Index】: R541.4
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