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《Anhui Medical and Pharmaceutical Journal》 2012-05
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Long-term toxicity study of schisandra sphenanthera softcapsule in rats

LI Lin-yan1,2,LIU Yan2,CAO Xiao-shuai1,et al(1.Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China; 2.Nanjing Hailing R&D for Chinese Traditional Medicine Pharmaceutical Technology,Nanjing 210049,China)  
Objective To observe the toxicity of continuous oral administration of Schisandra sphenanthera softcapsule in rats.Methods Rats were randomly divided into 3 groups,each group was given Schisandra sphenanthera softcapsule intragastrically in dose of 1.2、0.438,0.16 g·kg-1 for 13 weeks.Parameters were examined including general condition,body weight,food intake,blood cell,blood biochemistry,organ index,and pathological changes.Results Each drug group compared with the control had a reduction of spontaneous activity during the day.However,there was no significant difference at night.There were no significant differences in weight,organ coefficient,the indexes of haematology and biochemistry,pathological changes between the two groups.Conclusion Schisandra sphenanthera softcapsule has no significant toxicity for long-term oral administration to rats,which can be used safely.
【Fund】: 南京市2010年第二批科技发展计划项目(No 201002018)
【CateGory Index】: R285.5
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