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Li Feng,Zhang Xiaoming,Zhang Yun,Ye Chuanhui,Cheng Qingli (Department of TCM,Xijing Hospital,Fourth Military Medicial University,PLA,Xi’an 710032,China)  
Objective:To approach the mechanism of SKI on prohibiting Glomerulosclerosis(GS) so that treatment on chronic renal failure(CRF) with SKI furnishs fresh evidence in the level of cytobiology.Method:Using serumpharmacological test of Chinese medicinal herbs,we observed that how did SKI stimulates endothelin 1(ET 1) and nitric oxide(NO) secretion in cultured human glomerular mesangial cell(GMC).Result:SKI and SKI serum restrained significantly level of ET 1 and promoted NO secretion in GMC(P0.05),showing dependence on concentration.Working together with herparin,effect of SKI could been strengthened.Conclusion:Modulating production of NO,ET 1 is one of the mechanism of SKI on prohibiting GS,and the important link of SKI on preventing and treating CRF.
【CateGory Index】: R285.5
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