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《JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE》 2000-03
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EFFECT ANALYSIS OF ANTIHERPES SIMPLEX VIRUS TYPEHSV_(-2) WITH COMBINATION OF RHIZOMA POLYGONI CUSPIDATI AND ASTRAGALUS MEMBRANACEUS

Wang Zhijie,Huang Tieniu (Virus Research Institute,Hubei Medical University,Wuhan 430071,China)  
Objective:In order to obtain the most excellent dispensing proportion of Chinese medicinal herbs,we carry out this research.Method:we use ACV as positive control,observe antiherpes effects on HSV -2 333 strain of rhizoma polygoni cuspidati and astragalus membranaceus which are used lonely or in combination byplaque reduction assay,and make effect analysis of combination by median effect principle.Result:In HEp -2 cell system,the ED 50 s of the direct virucidal activity,the inhibition effects on the multiplication and infection of HSV -2 333 strain of ACV are 16.45,10.85 and 18.12μg/ml respectively.When combination ratio of rhizoma polygoni cuspidati/astragalus membranaceus equals 1(ED 50 ) of the former/1(ED 50 ) of the latter,the corresponding figures are 2.27,2.04 and 1.32μg/ml separately.Comparing with ACV,the effects is stronger than ACV,and the average combination index is the smallest,there is the most significant synergism.Conclusion:The treatment indices(TI) of the direct virucidal activity,the inhibition effects on the multiplication and infection of HSV -2 333 strain of this combination ratio are 726,525,1 400 times of ACV TIs respectively,it is the most excellent combination ratio.
【Fund】: 湖北省自然科学基金!(No .980J0 90 )
【CateGory Index】: R285.5
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