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《Journal of Anhui Traditional Chinese Medical College》 2000-06
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EFFECT OF HUOXUE TONGMAI TABLET ON HEMORRHEOLOGY AND HYPERLIPEMIA IN EXPERIMENTAL ANIMALS

HANG Li,MA Shi-ping,LONG Yin,FANG Kun-quan,WANG Zong-ren (Xijing Hospital,the 4th Military Medical University,PLA,Shaanxi Xi'an 710032,China)  
Objective:To observe the effects of Huoxue Tongmai tablet(HXTMT),the traditional Chinese drugs,on hemorrheology of experimental canine and hyperlipemia of experimental SD rats.Method:The coronary artery ligation was employed to establish a myocardial ischemia model with canine(blood stasis).Coronary sinus cannula was inserted through the exteral jugular vein and HXTMT was duodenally perfused;hemorrheological indexes were observed.Rats fed with a lipid-rich diet for 2 weeks and the mimic model of hyperlipemia was established;experimental tablets were given to the rats by gastrogavage,and blood lipid was assayed on the 15th day.Result:In comparison with control group,HXTMT sigmificantly reduced whole blood high and low-shear viscosity,plasma viscosity and erthrocyte electrophoretic time(EET) in myocardial ischemia canine(P0.05,P0.01);on the other hand,HXTMT reduced the serum of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-c)in rats.Conclusion:HXTMT can be used to improve the hemorrheology of canines with acute myocardial ischemia and hyperlipemia of rats.
【Fund】: 中国人民解放军军队新药研究重点课题!(No .118 (1998) )
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