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EFFECTS OF YIZHILING CAPSULE ON LEARNING AND MEMORY ABILITY AND CHOLINESTERASE ACTIVITIES IN MICE MODEL

YU Jian ping,ZHANG Cheng wei (The First Affiliated Hospital of Anhui Medical University,Anhui Hefei 230022,China)  
Objective:To observe the effects of Yizhiling capsule on learning and memory ability and cholinesterase activities in mice model by classic learning and memory tests.Method:Learning and memory ability was examined for mice by scopolamine model,ethanol model and chloramphenicol model.Cholinesterase activities in brain were determined by microdosage hydroxylamine method.Result:Yizhiling capsule could significantly antagonize the decline of learning and memory function induced by scopolamine,ethanol and chloramphenicol in mice. Cholinesterase activities in brain were reduced in comparison with those of model group(P0.01).Conclusion:Yizhiling capsule has protective effect on declined function of cholinergic system.
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