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《Journal of Anhui Traditional Chinese Medical College》 2002-01
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EFFECT OF QIDAN TONGMAI TABLET ON LEVEL OF SERUM NITRIC OXIDE AND PLASMA ENDOTHELIN IN CANINES WITH ACUTE MYOCARDIAL ISCHEMIA

LI Jing hua, WANG Zong ren, XIAO Tie hui, MA Shi ping, MA Jing, XIA Tian, LI Jun chang (Xijing Hospital, The 4th Military Medical University, PLA,Shaanxi Xi′an 710032, China)  
Objective:To study the effect of Qidan Tongmai Tablet (QDTMT) on the concentration of plasma endothelin(ET) and serum nitric oxide(NO) of canines with acute myocardial ischemia(AMI). Method: The left anterior descending branch of coronary artery ligation was employed to establish AMI and myocardial infarction model. Coronary sinus cannula was inserted through the external jugular vein, and QDTMT was duodenally perfused. The content of ET and NO were measured before and after the ligation. The cardiac muscular tissues of ischemic area were removed for detecting the concentration of NO and ET of cardiac muscular tissue homogenate. Result: The plasma NO increased significantly in AMI canines. Compared with that of the control group, high dose administration of QDTMT increased the concentration of plasma NO, and reduced that of plasma ET significantly especially after administration of QDTMT 30 min in high dose group (P0.05). Conclusion: QDTMT has obvious effects on ET and NO in AMI canines. The effects of QDTMT on promoting the synthesis of NO, inhibiting that of ET are possibly associated with the protective mechanism against AMI.
【Fund】: 中国人民解放军新药研究重点项目 (1 1 8(1 998) )
【CateGory Index】: R285.5
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