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《Journal of Anhui Traditional Chinese Medical College》 2002-02
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INFLUENCE OF XINFENG CAPSULE ON SERUM LEVEL OF IL-1, TNFα,IL-4,AND IL-10 IN ADJUVANT ARTHRITIS RATS

LIU Jian,HAN Ming xiang,ZHANG Wan dong,CHEN Guang liang,LEI Li (The First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China)  
Objective:To observe the effects of Xinfeng capsule(XFC) on the levels of interleukin 1(IL 1),tumor necrosis factor α (TNFα), interleukin 4 (IL 4), interleukin 10 (IL 10) of adjuvant arthritis rats. Method: 50 rats were averagely divided into normal control group, model control group, XFC treated group, tripterygium wilfordii polycoride tablet (TPT) treated group, methotrexate (MTX) treated group. Except for the rats of normal control group, the others were intracutaneously injected with 0.05 ml of Freung′s complete adjuvant in the right hindlimb. The serum cytokine levels of each rat were assayed. Result:The arthritis index (AI) of XFC, TPT,MTX treated group was markedly decreased after treatment (P0.05 or P0.01). The increment of rat body weight (BW) in XFC treated group wasn′t significantly different from that of normal control group (P0.05). The increment of rat BW of TPT, MTX treated group was significantly lower than that of XFC treated group, normal control group (P0.01). The IL 1 level of XFC treated group was ob viously decreased in comparison with that of model control group, and IL 4,IL 10 level significantly increased (P0.01). There was no significant difference between the IL 1, TNFα, IL 4,and IL 10 levels of XFC treated group and the other two treatment group (P0.05). Conclusion: The effect of XFC on the decrement of AI is the same as that of TPT, MTX in adjuvant arthritis rats, while effect of XFC on the increment of BW is superior to that of TPT, MTX. XFC decreases AI, eliminates swelling by down regulating the levels of IL 1, TNFα, up regulating the levels of IL 4, IL 10, restraining the inflammatory reaction.
【Fund】: 卫生部优秀青年科研基金项目 (992 6 )
【CateGory Index】: R259.9
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