PROTECTIVE EFFECTS OF TOTAL GLUCOSIDES OF PAEONY AND EXTRACT FROM ANGELICA SINENSIS ON EXPERIMENTAL HEPATITIS
CHEN Xiang qing,WANG qin mao,FANG Hua wu,SU Cui mei (Dept. Of Pharmacy, Anhui Provincial Hospital,Anhui Hefei 230001,China)
Objective:To study the protective effects of total glucosides of paeony (TGP) and extract from Angelica sinensis (EAS) on experimental hepatitis. Method: Mouse acute liver injury model was induced by D galactosamine (D GL)or carbon tetrachloride(CCl 4).Result:The decrease of ALT, AST, ALP, and the increase of GSH in serum,which were induced by D GL or CCl 4,could be antagonised by TGP and EAS, the hepato cellular degeneration and necrosis induced by D GL could also be diminished. The optimal dosage is TGP(200 mg·kg 1 /d, 7 d, ig) plus EAS (153.4 g·kg 1 /d,7 d, ig). Conclusion: Pre treatment with TGP and EAS moderately prevents the liver damage induced by D GL or CCl 4.