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《Journal of Anhui Traditional Chinese Medical College》 2003-03
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Effect of Brucine on Proliferation of Rabbit Chondrocyte

ZHANG Mei, LI Ping (Anhui Provincial Hospital, Anhui Hefei 230001, China)  
Objective:To observe the effect of brucine on proliferation of chondrocyte with monolayer culture technique. Method: Rabbit chondrocytes were isolated and cultured in vitro.The cell proliferation was tested by methylthiazolyl tetrazolium (MTT) method. Result: The cell proliferation rate of high, middle and low dosage of brucine groups was higher than that of the blank control group (P0.05). Nitric oxide could inhibit chondrocyte proliferation. Brucine could antagonize the inhibitive action of nitric oxide on chondrocyte proliferation. Conclusion: Brucine can effectively promote the proliferation of chondrocyte.
【Fund】: 国家中医药管理局资助项目 (2 0 0 JP 5 8)
【CateGory Index】: R285.5
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