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《Journal of Anhui Traditional Chinese Medical College》 2003-04
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Effects of Emodin Extracted from Rhizoma Polygoni Cuspidati in Treating HSV-1 Cutaneous Infection in Guinea Pigs

WANG Zhi-jie,HUANG Tie-niu,GUO Shu-fang,WANG Rui-hua (Virus Research Institute,Medical College of Wuhan University,Hubei Wuhan 430071,China)  
Objective:To investigate anti-herpes effects of emodin extracted from Rhizoma Polygoni Cuspidati on human simplex virus type-1(HSV-1) in vivo.Method:By using acyclovir(ACV) as positive control,and PBS and 1.0 ml/L Tween-80+PBS as negative control,using guinea pig model of cutaneous HSV-1 infection,the anti-herpes effects of emodin extracted from Rhizoma Polygoni Cuspidati were observed.Result:The cumulative scores of the regions dealt with ACV,emodin were (14.20±6.70),(7.00±6.16) respectively;the time to healing of the regions dealt with ACV,emodin were (7.70±1.08)d,(6.30±1.40)d separately,these results had significance in statistics compared with the regions dealt with PBS and PBS+1.0 ml/L Tween-80,and corresponded with the virus titre of skin samples.Conclusion: The anti-herpes effects of emodin are better than those of ACV,and it is worth exploiting.
【Fund】: 湖北省自然科学基金项目 (980J0 78)
【CateGory Index】: R285.5
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