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《Journal of Anhui Traditional Chinese Medical College》 2004-01
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Dynamic Changes of Contents of cAMP and cGMP in the Cerebral Tissue and Plasma in Rats with Qi-deficiency and Blood-stasis Syndrome Following Focal Cerebral Ischemia and Reperfusion

HU Jian peng, L Lei Tutor:Professor WANG Jian (Department of Integrated Traditional Chinese and Western Medicine, Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038, China)  
Objective:To establish the animal model of Qi deficiency and blood stasis syndrome following focal cerebral ischemia, and investigate the dynamic changes of cyclic adenosine monophosphate(cAMP) and cyclic guanosine monophosphate(cGMP) in the animal model of combination of disease with syndrome. Method: The animal model of Qi deficiency and blood stasis syndrome was formed by starvation, fatigue, cold wetness, panic and high grease diet in rats. The animal model of focal cerebral ischemia was formed by intraluminal thread occlusion of the middle cerebral artery. The middle cerebral arteries of rats were occluded for 2 hours and reperfused for 1~7 days. The cAMP and cGMP contents were observed in plasma and hippocampus and cerebral cortex of frontal or parietal lobe. Result: The cAMP contents in plasma and cerebral tissue were significantly higher, they were highest 3 days later in plasma or 1 day later in cerebral tissue;the cGMP contents decreased obviously ,they were lowest 1 day later in cerebral tissue and plasma. Conclusion: The rat model are almost in accordance with the peculiarity of Qi deficiency and blood stasis syndrome and the pathologic characteristics of cerebral ischemia reperfusion.
【CateGory Index】: R363
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