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《Journal of Anhui Traditional Chinese Medical College》 2004-02
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Effect of Kidney-supplementing, Qi-invigorating and Blood-activating Prescription on Proliferation and Apoptosis of Chondrocytes in Rabbits

TANG Yong, MA Min,CAO Yong, ZHOU Yong Hong, SUN Li,JIANG Jie (The Department of Traditional Chinese Medicine, Medical College of Ji′nan University,Guang dong Guangzhou 510632, China)  
Objective: To observe the effects of kidney supplementing, Qi invigorating and blood activating (KQB) Prescription containing serum on proliferation and apoptosis of rabbit chondrocytes in vitro. Method: The chondrocytes were isolated from the cartilage of the rabbits, and were divided into 5%, 10%, 20% KQB prescription containing serum groups and control group. After the chondrocytes were cultured for 7 days in 37℃,50 ml/L CO 2 incubator, their proliferation, apoptosis and the telomerase activity were detected with MTT, TUNEL and PCR ELISA respectively. Result: The proliferation of chondrocytes in 5%,10% ,20% KQB prescription containing serum groups were respectively higher than those in control group(P0.05);their apoptosis were respectively lower than those in control group(P0.05);their telomerase activity were respectively higher than those in control group(P0.01). Conclusion: KQB Prescription can inhibit the apoptosis of chondrocytes by up regulating the telomerase activity.
【CateGory Index】: R285.5
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