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《Journal of Anhui Traditional Chinese Medical College》 2004-02
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Effect of Cough-easing Granule on Histological Morphology of the lungs and Bronchus in Mice with Chronic Bronchitis

JIANG Feng rong, DAI Xiao ming, HUANG Yu fang, TANG De cai, CHEN Xue qing (The Basic Department of Nanjing University of Traditional Chinese Medicine, Jiangsu Nanjing 210029, China)  
Objective:To observe the influence of Cough easing Granule on the histological morphologic changes of the trachea and lungs in mice with chronic bronchitis. Method: The rat model of chronic bronchitis was simulated by injecting lipopolysacchride into the trachea, and the model rats were divided into model group, positive control group, group treated with small dosage of Cough easing Granule, group treated with high dosage of Cough easing Granule. Result: The epithelium of bronchus in model group was mortified and desquamated badly, and the bronchus expanded. A lot of lymph cells in the bronchus were infiltrated. Some alveolus changed like emphysema. The epithelium of the mouse bronchus in positive control group was mortified and desquamated slightly, and bronchus did not obviously expanded. Lymph cells were intact, and pathological changes were little. The epithelium of the mouse bronchus in Cough easing Granule treated group was mortified and desquamated in sheets, and the epithelium was proliferous. Lymph cells in the bronchus were infiltrated. The epithelium of the mouse bronchus in high dosage of Cough easing Granule treated group was intact, and lymph cells in the bronchus were infiltrated slightly. Mortification of mucous membrane of the bronchus in five groups had significant difference (P0.01). Conclusion: Cough easing Granule can alleviate chronic bronchitis. In morphology, after the treatment, damaged mucous membrane of the bronchus and lungs is improved. It shows that Cough easing Granule is effective to chronic bronchitis.
【CateGory Index】: R285.5
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