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《Journal of Anhui Traditional Chinese Medical College》 2004-03
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Changes of Fas and FasL Protein Expression of Lung Tissue in Rats with Pulmonary Qi Deficiency Syndrome

LI Ze geng, ZHANG Nian zhi, PENG Bo,ZHANG Jie gen, HAN Ming xiang (The First Hospital Affiliated to Anhui College of Traditional Chinese Medicine, Anhui Hefei 230031,China)  
Objective:To evaluate the expression of apoptosis related genes in rats with pulmonary Qi deficiency. Method: The rat pulmonary Qi deficiency model was established by intratracheal instillation of lipopolysaccharide(LPS) twice and exposed to cigarette smoke. By transmission electron microscope (TEM) and immunocytochemistry techniques, apoptosis and Fas,FasL protein expression were studied in two groups after 4 weeks. Result: Apoptosis ratio was obviously higher in the model group than that in the control group. Fas and FasL protein expression of lung tissues were up regulated in the model group.Conclusion:Fas and FasL may contribute to the pathogenesis of pulmonary Qi deficiency,and participate in cell apoptosis modulation of the lung tissues with pulmonary Qi deficiency.
【Fund】: 安徽省自然科学基金资助项目 (0 1 0 4 31 0 0 6 )
【CateGory Index】: R256.1
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【Co-citations】
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