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《Journal of Anhui Traditional Chinese Medical College》 2004-05
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Experimental Research on the Cholagogic Action of Gargenoside

SUN Xu-qun, ZHAO Xin-ming , YANG Xu (Dept. of Pharmacy,The First Hospital Affiliated to Anhui Medicine University,Anhui Hefei 230022,China)  
Objective: To observe the cholagogic action of gardenoside. Method : Normal rats and the rats with α-naphthy1-isothiocyanate(ANIT)-induced liver injury were treated with gardenoside and then observed the amount of bile excretion and the changes of cholesterol, bilirubin, direct bilirubin and unconjugated bilirubin after 6 hours.Result: The amount of bile excretion after 6 hours could be significantly improved in both normal rats and the rats with ANIT-induced liver injury by treating gardenoside-containing herbal medicine 0.2,0.4,0.8 and 1.6 g/kg(P0.05 or P0.01), meanwhile there was no obvious effect on cholesterol.bilirubin, direct bilirubin and unconjugated bilirubin. Conclusion:Gardenoside has cholagogic action.
【CateGory Index】: R285.5
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