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《Journal of Anhui Traditional Chinese Medical College》 2004-06
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Effect of Naoluoxintong on Neurocyte Apoptosis and P53 Protein Expression in Rats with Cerebral Ischemia-reperfusion Injury

LI Jing,HU Jian-peng,LIU Xin Tutor:Professor WANG Jian (Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China)  
Objective:To investigate the effects of Naoluoxintong, a traditional Chinese prescription, on the apoptosis of neurocytes and the expression of P53 protein in rats with Qi deficiency and blood stasis syndrome after local cerebral ischemia-reperfusion injury. Method: The model of Qi deficiency and blood stasis syndrome was made by means of combined factors of hunger, tiredness and high fat diet. The middle cerebral arteries (MCA) of rats were occluded for 2 hours and reperfused for 1,3 days respectively. The cell apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), and the expression of P53 protein was detected by immunohistochemistry method. Result: In the Naoluoxintong treated group, the cell apoptosis and P53 protein expression significantly decreased compared with those in model group (P0.01). Conclusion: The mechanism of Naoluoxintong in preventing neuron apoptosis induced by local cerebral ischemia-reperfusion associates with restraining the expression of P53 protein.
【Fund】: 安徽省自然科学基金资助项目 (No .0 0 0 4 4 116 ) ;; 安徽省教育厅科研基金资助项目 (No .99JL0 131)
【CateGory Index】: R285
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