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《Journal of Anhui Traditional Chinese Medical College》 2005-03
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Effects of Chinese Herbs of Strengthening Kidney and Activating Blood on the Level of the Nitric Oxide in Rabbits with Knee Osteoarthritis

NIU Wei, SHAO Min, LI Gao ming. (The Affiliated Hospital of Orthopaedics and Traumatology , Guang Zhou Traditional Chinese Medicine University,Guangdong Guangzhou 510240,China)  
Objective:To explore the effects of Chinese herbs of strengthening kidney and activating blood on netric oxide (NO) of serum, articular cartilage and synovial membrane in rabbits′ knee joints. Method: Fifty four New Zealand rabbits with 10 months were divided randomly into the normal group, model group and Chinese herb group. The rabbits in normal group underwent sham operation and others established the OA model with Hulth′s method. Chinese herb group were given Chinese herbs.The NO concentration of the serum, articular cartilage and synovial membrane in all rabbits were examined at 4, 8 ,12 weeks after operation. Result: The NO concentration of the serum, articular cartilage and synovial membrane in model group was all significantly higher than those in normal group, with the synovial membrane more obvious than others′. Compared with other groups, the NO concentration of Chinese herb group were obviously decreased( P 0.05). Conclusion:The Chinese herbs of strengthening kidney and activating blood was effective in preventing and treating osteoarthritis by decreasing the level of NO of the serum, synovial membrane and articular cartilage.
【Fund】: 广东省自然科学基金资助项目(020791);; 国家中医药管理局科学技术研究专项基金资助项目(0203JP33)
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 1 Hits
1 SHAO Min,CHEN Sui-xing,NIU Wei,LI Gao-ming(The Traumatic and Orthopedic Hospital Affiliated to Guangzhou University of Traditional Chinese Medcine, Guangdong Guangzhou 510240,China);Effect of Bushen Huoxue Fang on Histomorphometric Indexes in Experimental Osteoarthritis[J];Journal of Anhui Traditional Chinese Medical College;2006-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Department of traditional Chinese medicine,Anhui Provineical Hospital,Hefei 230001ZHANG Mei, CHEN Chao-hui, LI Ping;Research process of mechanism of traditional chinese medicine on osteoarthritis[J];Journal of Anhui Health Vocational & Technical College;2003-02
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