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《Journal of Anhui Traditional Chinese Medical College》 2005-03
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Study on the Compound Model of Hypertension and Hyperlipemia in Rats

LI Fei (Postgraduate student of Grade 2003,Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038, China)  
Objective:To set up the compound model of the hepertension and heperlipemia in rats. Method: Forty Wistar rats with half male rats and half female rats were randomly divided into normal group( n =10),pseudo surgery group( n =10) and model group( n =20). The compound model of the hypertension and hyperlipemia was made by means of the way of “2K1C” combined with pouring hyperlipemia food into rats′ stomach. Animal model was judged according to levels of blood pressure(BP), angiotensinⅡ(AngⅡ),total cholesterol(TC) and triglyceride(TG). Result: Levels of BP,AngⅡ,TC and TG significantly increased in model group in 4th week ( P 0.01 ), and kept steady in 6th week,compared with those in pseudo surgery group. Conclusion: The way of “2K1C” combined with pouring hyperlipemia food into rats′ stomach could set up the compound model of hypertension and hyperlipemia.
【Fund】: 安徽省自然科学基金项目(03043007)
【CateGory Index】: R-332
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