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《Journal of Anhui Traditional Chinese Medical College》 2005-06
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Effect of Zhihuang Fang on the Levels of Lipid Peroxidation of Liver and Stomach and Serum Alanine Aminotransferase in Rats with Alcoholic Liver Injury

PAN Ling,ZHANG Wei-li,QIU Rong-yuan,HU Sheng-jun,YANG Ling,PENG Han-guang(The Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430022,China)  
Objective: To explore the mechanism of Zhihuang Fang (ZHF),a traditional Chinese prescription,in the prevention and treatment of alcoholic liver injury.Method: In the ZHF-protecting experiment and the ZHF-treating experiment,the drunkenness time was recorded,and the activities of superoxide dismutase(SOD) and the concentration of malondialdehyde(MDA) in liver and gastric mucosa as well as the level of alanine aminotransterase(ALT) in serum were assayed by biochemistry and spectrophotometry.Result: In the ZHF-protecting experiment,ZHF could shorten the drunkenness time of rats(P0.05),significantly decrease the serum level of ALT and the concentration of MDA in the liver and gastric mucosa of rats with alcoholic liver injury(P0.05 or P(0.01)),and significantly increase the activities of SOD in the liver and gastric mucosa(P0.01).In the ZHF-treating experiment,ZHF had no effect on the drunkenness time,but it could decrease the concentration of MDA in the liver and the level of ALT in serum(P0.01),and increase the activities of SOD in the liver(P0.01).Conclusion: ZHF can antagonize the lipid peroxidation of the liver in rats with alcoholic liver injury,and protect the liver function.ZHF can prevent alcoholic liver disease before rats are filled with alcohol.
【CateGory Index】: R285.5
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