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《Journal of Anhui Traditional Chinese Medical College》 2006-01
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Clinical Study on the Improvement of Cellular Immune Function and Intestinal Mucosal Permeability by Dripping Chinese Medicinal Herbs into the Intestine in Early Postoperative Patients with Gastric Carcinoma

YU Qing-sheng,HOU Yong,ZHANG Fu-zhong,YI Wei-zhen,WANG Xiao-ming,CHEN Zi-yi (The Department of General Surgery,the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China)  
Objective: To observe the effects of traditional Chinese prescription for invigorating the spleen and purging the gastrointestinal tracts on the cellular immune function and intestinal mucosal barrier function in early postoperative patients with gastric cancer.Method: Sixty gastric cancer patients with operation indication were randomized into the observation group and the control group.Thirty patients were dripped with traditional Chinese prescription for invigorating the spleen and purging the gastroinstestinal tracts via the silicon catheters intubated into small intestine on the first postoperative day for 7 days,while the other 30 patients of the control group were dripped with 9.0 g/L normal saline on the first postoperative day,and the course of treatment was the same as that of the observation group.The observation parameters included cellular immune function,such as serum interleukin-2(IL-2),soluble interleukin-2 receptor(sIL-2R) and interleukin-12(IL-12) and intestinal mucosal permeability,such as lactulose and mannitol excretion ratio in urine as well as serum endotoxin before and after surgery.Result: The IL-2 level of the observation group increased significantly,while the level of sIL-2R decreased obviously as compared with that of the control group seven days after operation(P0.05).The levels of IL-2,sIL-2R and IL-12 of the observation group were obviously improved seven days after operation as compared with those one day before operation.While the above-mentioned indexes of the control group showed no significant difference between seven days postoperative and one day preoperative(P0.05).The excretion ratio of urine L/M of the observation group five days after operation was significantly lower than that of the control group(P0.01).But there was no significant difference in the observation group between five days postoperative and one day preoperative(P0.05).While the urine L/M excretion ratio obviously increased five days after operation as compared with that one day before operation.The ET level of the observation group three days after operation significantly decreased as compared with that of the control group(P0.01).The ET level of the observation group did not increased obviously three days after operation as compared with that one day before operation,while there was significant difference in the serum ET level of the control group between three days postoperative and one day preoperative.Conclusion: The early application of traditional Chinese prescription for invigorating the spleen and purging the gastrointestinal tracts in treating postoperative patients with gastric cancer can improve the cellular immune function and help the improvement of intestinal mucosal permeability and protect gut barrier function.
【Fund】: 国家中医药管理局基金项目(00-01LP01);; 安徽省教育厅自然科学基金项目(JL148)
【CateGory Index】: R735.2
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【References】
Chinese Journal Full-text Database 7 Hits
1 YU Hong-liang,YU Qing-sheng(Department of General Surgery,the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);The Effects of Qihuang Decoction on Intestinal Epithelial Morphology in Rats Undergone Ischemia Reperfusion Injury[J];Journal of Anhui Traditional Chinese Medical College;2009-03
2 YU Qing-sheng1,ZHANG Yan2,PAN Jin-fang1,WANG Han-ming1,SHUAI Jian-feng1,ZHANG Qi1,LIU Ju-da1(1.Department of General Surgery,the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China;2.Anqing Municipal Hospital,Anhui Anqing 246003,China);Effect of Qihuang Decoction on Anti-inflammatory Cytokines and Their mRNA Expression in Early Postoperative Patients with Gastric Carcinoma[J];Journal of Anhui Traditional Chinese Medical College;2010-06
3 CHEN Wen,SHU Peng Nanjing University of TCM,Nanjing Jiangsu China;The Research Status of Treating Gastric Cancer with Traditional Chinese Medicine of Strengthening Spleen and Warding off Disaster[J];Gansu Journal of Traditional Chinese Medicine;2011-04
4 LIU Ju-da,YU Qing-sheng,WANG Dong-ming,CHEN Gang,YUAN Yi-yang,ZHANG Qian-yi(The Department of General Surgery,the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);Effects of Qihuang Decoction on Lymphocytes inside Peyer's Patches in Rats with Stomach Excision[J];Journal of Anhui Traditional Chinese Medical College;2011-03
5 Yu Qingsheng,Zhang Qi,Pan Jinfang,et al. Department of General Surgery,First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Hefei(230031),China;Effect of Qi Huang(芪黄) Decoction on Immunity Function and Bowel Mucosal Barrier on Early Days after Gastric Cancer Operation in Rats[J];Chinese Journal of Surgery of Integrated Traditional and Western Medicine;2009-02
6 YU Hong-liang,YU Qing-sheng,PAN Jin-fang,et al Department of General Surgery,The First Affiliated Hospital of Anhui university of Traditional Chinese Medicine,Hefei (230031);Effect of Qihuang Decoction on Epithelial Cell Apoptosis of Ischemia/reperfusion Injured Intestinal Mucosa in Rat[J];Chinese Journal of Integrated Traditional and Western Medicine;2009-12
7 YU Qing-sheng,YU Hong-liang,PAN Jin-fang,et al Department of General Surgery,The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Hefei (230031);Effect of Qihuang Decoction on mRNA Expressions of Bcl-2,Bax,and Caspase-3,9 in Intestinal Mucosa Epithelium of Ischemia/Reperfusion Injured Rats[J];Chinese Journal of Integrated Traditional and Western Medicine;2011-02
【Citations】
Chinese Journal Full-text Database 8 Hits
1 QUAN Zhu fu, YANG Chong, LI Ning, LI Jie shou (Research Institute of General Surgery,Nanjing General Hospital of Nanjing Command,Nanjing 210002,Jiangsu,China);Change in early postoperative intestinal permeability and its relation with systemic inflammatory response[J];Parenteral & Enteral Nutrition;2002-02
2 ZHANG Mei 1, XIA Tian 1, ZHANG Zhong Hai 1, JIN Feng Shuo 3, YAN Zhen 2, CUI Da Xiang 2 1Department of Traditional Chinese Medicine, Xijing Hospital, 2Centre of Biologic Technology,Fourth Military Medical University, Xi’an 710033, China;Effects of Sijunzi decoctum on plasma cytokines in patients with TCM pixu[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-04
3 Wen Huai-kai, et al. Laboratory Department, Second Hospital, Wen Zhou Medical College;ANALYSIS OF SERUM CYTOKINES LEVELS IN GASTRIC CANCER PATIENTS BEFORE AND AFTER SURGICAL OPERATION[J];Journal of Radioimmanology;1998-05
4 Ling Rui, Wang Junyi, Wang Weizhong, et al. (Department of Gastrointestinal Surgery, Xijing Hospital of the Forth Military Medical University, Xi’an 710032);The Study on Kinetics of sIL 2R and IL 2 in Serum of Patients with Gastric Cancer during Perioperative Period[J];JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY;1997-01
5 Xie Jiliang,Zhang Zhiyao,Wu Xianzhong Tianjin Nankai Hospital,Tianjin(300100);The Gut Barrier Protective Effects of Cheng Qi Prescription in Treatment of MODS[J];Chinese Journal of Surgery of Integrated Traditional and Western Medicine;2002-03
6 Yu Qingsheng; Cheng Ziyi; Tang Xiongrong(Affiliated Hospital of Anhui College of Traditonal Chinese Medicine,Hefei,230031);Effect of Qihuang Decoction on Lymphocyti Immune Function after Radical Gastrectomy[J];CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE;1996-02
7 Jin Jingshan et al. Beijing Institnte of TCM(100010);A Study on the Relationship between Spleen qi deficiency Symptom and Neuro endocrino immounologic Network[J];CHINA JOURNAL OF BASIC MEDICINE IN TRADITIONAL CHINESE MEDICINE;1997-03
8 Chang Zhen HosptialChen Dechang,et al.;The Effect of Rhubarb on Intestinal Permeability of Rats with Hemorrhagic Shock[J];;1994-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YU Qing-sheng1,ZHANG Yan2,PAN Jin-fang1,WANG Han-ming1,SHUAI Jian-feng1,ZHANG Qi1,LIU Ju-da1(1.Department of General Surgery,the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China;2.Anqing Municipal Hospital,Anhui Anqing 246003,China);Effect of Qihuang Decoction on Anti-inflammatory Cytokines and Their mRNA Expression in Early Postoperative Patients with Gastric Carcinoma[J];Journal of Anhui Traditional Chinese Medical College;2010-06
2 LU Ding-bo,Zhang Chi-zhi,YAN Xue-sheng,XIAO Lin(Hubei Hospital of Traditional Chinese Medicine,Wuhan 430061,China);Effect of Ruhuang preparation on endotoxin and intestinal defence function of cirrhotic rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-09
3 SONG Fu-lin1,LIN Yi-fan2,LI Hao-ran2,LU Yu-ping2,YANG Zhuo2,GAO Wen-yan2,GONG Yang2,LIU Yang2,CHEN Shan-quan2,WANG Chang-hong2(1Department of Pathology,Hospital of Shenyang Military District,Shenyang 110015,China;2Department of Traditional Chinese Medicine,Hospital of Shenyang Military District,Shenyang 110015,China);Effect of Jiawei Sijunzi decoction based triple therapy on atrophic gastritis and expression of PCNA[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-03
4 QUAN Zhu-fu,YUAN Zhi-chao, LI Jie-shou(Research Institute of General Surgery, Jingling Hospital, Medical College of Nanjing University, Nanjing 210002, Jiangsu, China);Effects of alanyl-glutamine dipeptide on postoperative intestinal permeability and stress response[J];Parenteral & Enteral Nutrition;2008-06
5 QUAN Zhu-fu,YUAN Zhi-chao,LI Jie-shou(Research Institute of General Surgery,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China);Effects of alanyl-glutamine dipeptide administration on postoperative intestinal permeability and systemic inflammatory response[J];Parenteral & Enteral Nutrition;2010-01
6 YU Jie,GONG Zhi-lin.Department of Gastrointestinal Surgery,Central Hospital of Jingzhou,Jingzhou 434020,China;Intestinal permeability and early inflammatory response following stomach carcinoma operation[J];Journal of Abdominal Surgery;2010-06
7 LIU Chun-an,XIAN Pei-zhong,KANG Xu,XU Qing-wen,LI You-zhu(Department of Gastrointestinal Surgery,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China);Intestinal permeability and inflammatory response following colonic surgery[J];Journal of Guangdong Medical College;2007-04
8 LI Dan ,ZENG Bo-heng ,YU Sian(1 Department of Oncology, Second Affiliated Hospital, Guangzhou Medical College,2 Department of Nuclear Medicine, Second Affiliated Hospital,Guangzhou Medical College, Guangzhou 510260);Expression of Transforming Growth Factor-alphaand Epidermal Growth Factor in Patientswith Malignant Tumors[J];Academic Journal of Guangzhou Medical College;2001-04
9 LIU Jing, ZHANG Jiayun, ZHAO Jiali, et al∥(Department of General Surgery, Mile People’s Hospital, Mile 652300, China);Effect of Colon Lavage with Chinese Traditional and Western Medicines on Acute Pancreatitis[J];Journal of Nursing Science;2005-06
10 Sun JiahongAnhui College of Traditional Chinese Medicine, Hefei, Anhui, China, 230038;Study of Prescription to Treat Deficiency of Spleen-qi on the Angle of Prescription Syndrome Integration[J];Journal of Henan University of Chinese Medicine;2007-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YU Hong-liang,YU Qing-sheng(Department of General Surgery,the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);The Effects of Qihuang Decoction on Intestinal Epithelial Morphology in Rats Undergone Ischemia Reperfusion Injury[J];Journal of Anhui Traditional Chinese Medical College;2009-03
2 YANG Jian-Wei1, CHEN Yi-Gui1, CHEN Qiang1, FAN Nan-Feng1, GUO Zeng-Qing1, CAI Xiong-Chao1, WU Xiao-An2, XU Shen3, LU Xia4, ZHANG Ying-Hong5, OUYANG Xue-Nong6 1. Department of Medicine, Fujian Provincial Tumor Hospital, Fuzhou, Fujian, 350014, P. R. China 2. Department of Oncology, Xiamen Municipal 174 Hospital, Xiamen, Fujian, 361000, P. R. China 3. Department of Oncology, Zhangzhou Municipal Hospital, Zhangzhou, Fujian, 363000, P. R. China 4. Department of Oncology, Zhongshan Hospital, Xiamen, Fujian, 361000, P. R. China 5. Department of Oncology, The First Hospital of Xiamen City, Xiamen, Fujian, 361000, P. R. China 6. Department of Oncology, Fuzhou Municipal 93 Hospital, Fuzhou, Fujian, 350000, P. R. China;A Randomized Controlled Trail of Taxol-based Combination Regimens for Advanced Gastric Cancer[J];Chinese Journal of Cancer;2005-12
3 LI Jian1,GU Wei1,HU Mei-jie2,SUN Ying1,WANG Ji1,ZHANG Ye-li2(1.Department of Gastroenterology,Luwan Branch Ruijin Hospital,Medical College of Shanghai Jiaotong University,Shanghai 200020;2.Department of Gastroenterology,Ruijin Hospital,Medical College of Shanghai Jiaotong University,Shanghai 200025,China);Analysis of the immunologic function in patients with gastric cancer[J];Journal of Bengbu Medical College;2009-08
4 Chen LiangLiang,Wu Liangcun, Li Qingxia,et al Zhejiang provincial Hospital of TCM,Hangzhou(310006);Experimental Study of Danshen Injection on TILS' Expansion in Vitro and Cytotoxicity[J];Journal of Zhejiang College of Tcm;2002-03
5 Yu Yong,Zhang Li,Cai Qianrong,et al Zhejiang Shengli Tongde Hospital,Hangzhou(310012);Revised Pinellia Combination Treat Digestive Tract Reaction from Chemical Therapy after Operation of Gastric Cancer[J];Journal of Zhejiang University of Traditional Chinese Medicine;2006-04
6 Qiu Jiaxin et al. (Affiliated Longhua Hospital of Shanghai College of TCM, Shanghai);Effect of Chinese Herbs for Invigorating the Spleen and Tonifying the Kidney on Initiation and Promotion of Multiple Step Theory of Tumor Formation[J];;1993-05
7 Wang Chunxia Hou Lianbing (Nanfang Hospital, Southern Medical University);Prevention Action of Changtong Oral Liquid on Postoperative Intestinal Adhesions in Rabbits[J];China Journal of Traditional Chinese Medicine and Pharmacy;2005-07
8 LI Xiu liang, GAOYong xiang, ZHOUShu fang, et al Clinical Medicine College, Chengdu University of Traditional Chinese Medicine (Chengdu,610075,China);Influence on Yi-yuan Zhi-xie Granules to Intestines Flora of Diarrhea due to Spleen Asthenia Mice[J];Journal of Chengdu Unversity of Tarditional Chinese Medicine;2001-03
9 YU Qing-sheng,PAN Jin-fang,YU Zong-fan,et al(The Department of General Surgery,the First Affiliated Hospital,Anhui College of TCM,Hefei anhui 230031);Effect of Early Intestinal Dripping of Chinese Herbs Qihuang Decoction on MOT and VIP and SS in Patients with Gastric Cancer after Operation[J];Journal of Chengdu University of Traditional Chinese Medicine;2008-03
10 WANG Jinrong, WANG Hongwei Department of Paediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Inflammatory reflex—cholinergic anti-inflammatory pathway[J];Chinese Journal of Neuromedicine;2004-04
China Proceedings of conference Full-text Database 1 Hits
1 Feng Lei, Jin Jian, Tao Wen-yi, Zhang Lian-feng (Department of Pharmaceutical and Molecular Biotechnology, School of Biotechnology, Southern Yangtze University, Wuxi, PR China 214036 );Studies on molecular mechanism of resveratrol to anticancer[A];[C];2006
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 YU Qing-sheng1,ZHANG Yan2,PAN Jin-fang1,WANG Han-ming1,SHUAI Jian-feng1,ZHANG Qi1,LIU Ju-da1(1.Department of General Surgery,the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China;2.Anqing Municipal Hospital,Anhui Anqing 246003,China);Effect of Qihuang Decoction on Anti-inflammatory Cytokines and Their mRNA Expression in Early Postoperative Patients with Gastric Carcinoma[J];Journal of Anhui Traditional Chinese Medical College;2010-06
2 LIU Ju-da,YU Qing-sheng,WANG Dong-ming,CHEN Gang,YUAN Yi-yang,ZHANG Qian-yi(The Department of General Surgery,the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);Effects of Qihuang Decoction on Lymphocytes inside Peyer's Patches in Rats with Stomach Excision[J];Journal of Anhui Traditional Chinese Medical College;2011-03
3 WANG Fei,XIA Yong-liang,LI Da-wei,WEI Xing(The First Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310006,Zhejiang,China);Clinic observation on TCM syndrome evolvement of postoperative gastric carcinoma[J];Chinese Archives of Traditional Chinese Medicine;2010-09
4 YU Hong-liang,YU Qing-sheng,PAN Jin-fang,et al Department of General Surgery,The First Affiliated Hospital of Anhui university of Traditional Chinese Medicine,Hefei (230031);Effect of Qihuang Decoction on Epithelial Cell Apoptosis of Ischemia/reperfusion Injured Intestinal Mucosa in Rat[J];Chinese Journal of Integrated Traditional and Western Medicine;2009-12
5 YU Qing-sheng,YU Hong-liang,PAN Jin-fang,et al Department of General Surgery,The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Hefei (230031);Effect of Qihuang Decoction on mRNA Expressions of Bcl-2,Bax,and Caspase-3,9 in Intestinal Mucosa Epithelium of Ischemia/Reperfusion Injured Rats[J];Chinese Journal of Integrated Traditional and Western Medicine;2011-02
6 Weng Li-xin1,Li Xiu-xia2,Fu Xiao-bing3 1Department of Pathology,Inner Mongolia Medical College,Hohhot 010059,Inner Mongolia Autonomous Region,China;2Department of Pathology,Affiliated Hospital of Inner Mongolia Medical College,Hohhot 010059,Inner Mongolia Autonomous Region,China;3Laboratory of Wound Repair,General Hospital of Chinese PLA,Beijing 100853,China;Effects of exogenous acidic fibroblast growth factor on the expression of p38MAPK and fibroblast growth-factor receptor 2 in rats with intestinal ischemia-reperfusion injury[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-50
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Li jun you, Lu Yi,Jin Hua,Sun Xiaoqin, Jiang Xiaoguo,Sheng Zhiyone (Burn institute 304 Hospital of people's liberation army, Beijing 100037);Sequential changes of diamine oxidase activity after trauma[J];Amino Acids & Biotic Resources;1999-03
2 Li Ning,Liu Fangnan,Li Yousheng et al Rasearch Institute of General Surgery,Nanjing General Hospital of PLA(Nanjing,210002);The changes of plasma glutamine and its influence on intestinal permeability after abdominal surgery[J];PARENTERAL & ENTERAL NUTRITION;1998-01
3 $$$$;The determination of Glu and Gln in plasma and tissue by RP-HPLC[J];ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE;1995-02
4 LUO Fu-dong,WU Xin-zhong,CHEN Fu,et al.Clinical Laboratory,Ersha Island Branch,Guangdong Provincal Hospital of TCM,Guangzhou 510105,China;The value of serum soluble transferrin receptor in the diagnosis of anemia of rheumatoid arthritis[J];Guangdong Medical Journal;2008-01
5 Xiu Fangming;Cao Xuetao; Yang Sikun; Xu Zhigong; Ye Tianxing(DepartmenofImmunology,The Second Military Medical University,Shanghai 2004 33);The Experimental Study on the in Vivo Induction of the Cytotoxicityof Killer Cells by Tumor Cells Transfected with TNF-aGene[J];IMMUNOLOGICAL JOURNAL;1995-03
6 Liu Xiaopeng,Zhang Xin,Chen Zirong,Zhang Guoan,Lin Hua,Zheng Ying(Department of Immunology of 476 Hospital,Fuzhou 350002);Effect of TNF on Patients of Carcinoma of Stomach byseveral Mito-gents and Treatment[J];IMMUNOLOGICAL JOURNAL;1995-04
7 Liu Nongle,Wang Fang,Jing Zihui,Zhang Lei,Xu Zhaopeng, Chen Jiankui,Wang Huixin, Chen Ai, Li Meijia(Institute of Basic Medical Science,Academy of Military Medical Science,Beijing 100850);Chemiluminescence Immunoassay for EpidermalGrowth Factor andit’s Clinical Application[J];IMMUNOLOGICAL JOURNAL;1995-04
8 Zhang Jianxin,Gao Shouguo (Department of analytical chemistry,Nanjing Railway Medical College,Nanjing,210009);Malondialdehyde Kit for Determining Serum Lipoperoxide[J];JOURNAL OF NANJING RAILWAY MEDICAL COLLEGE;1997-01
9 Douglas W. Wilmore,M. D. (Department of surgery Blighan and Women's Hospital,Boston ,Mass,USA);The gut after surgical stress[J];Chinese Journal of Clinical Nutrition;1993-01
10 (大承气汤)Xie Ji-liang;Zheng Xian-li;Wu xjan一zhong (Tian jin Research Institute of Abdominal Diseases,Tian jin Mankai Hospital(300100));Research on Prevention and Treatment of Endotoxemia in Acute Intra-abdominal Infection With Da Cheng Qi Decoction[J];CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE;1994-01
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