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《Journal of Anhui Traditional Chinese Medical College》 2007-03
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Study on the Anti-coagulation Mechanism of Total Paeony Glycosides

WU Zhang-bao,WANG Ting,LIU Qing-yun,CHEN Li-ming(Anhui Provincial Hospital,Anhui Hefei 230001,China)  
Objective: To investigate the anti-coagulation mechanisms of total paeony glycosides(TPG).Methods: The clotting time(CT),prothrombin time(PT) and thrombin time(TT) of mice,the activities of blood coagulation factorⅡ,Ⅴ,Ⅶ,Ⅷ,Ⅸ,Ⅹ,Ⅺ,Ⅻ(FⅡ,FⅤ,FⅦ,FⅧ,FⅨ,FⅩ,FⅪ,FⅫ),and the fibrinogen level of rats were tested by Clotting Method.The activities of antithrombin-Ⅲ and protein C of rats were also tested by Colorimetry Method.Results: TPG can prolong the CT,PT and TT of mice,reduce the activities of FⅡ,FⅤ,FⅨ,and increase the activity of antithrombin-Ⅲ.Conclusion: TPG has the effectiveness of anti-coagulation,and some relative mechanisms are found.
【CateGory Index】: R285.5
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