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《Journal of Anhui Traditional Chinese Medical College》 2007-06
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Effects of Huangpu Tongqiao Capsule on the Contents of cGMP and NO and Activities of NOS in Neurons of Rats with Vascular Dementia

CAO Shi-jian,XIE Dao-jun,JIANG Ting-zhan,WANG Yuan-jin,LI Zhi-he,HUANG Wei,LIU Ni,CHEN Yong-hua(The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Anhui Hefei 23038,China)  
Objective:To probe into mechanisms of effects of Huangpu Tongqiao Capsule(HTC) on the contents of cyclic guanosine monophosphate(cGMP) and nitric oxide(NO) and activities of nitric oxide synthase(NOS) in neurons of rats with vascular dementia(VaD).Methods:The rat VaD model was made by embolizing middle cerebral artery with threads,and the changes of the contents of cGMP and NO and activities of NOS in neurons of VaD rats in each group were observed.Results:After 4 weeks,the contents of cGMP and NO and activities of NOS in neurons of rats increased in model group compared with those of the control group,and significantly increased in Chinese medicine group compared with those of the model group(P0.01).Conclusions:HTC may reduce neuronal apoptosis induced by NO pathway and decrease neuronal toxicity,and enhance abilities of learning and memory by lowering the content of NO to a proper level.The abovementioned effects might be important mechanisms for the treatment of VaD.
【Fund】: 合肥市科技局重点科研项目(合科[2003]33号)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Yuan-jin1, XIE Dao-jun2,MA Ke-long1, NA Sha1, BAI Mei1 (1.Dept of Integrated Traditinal and Westrn Medicine,Anhui College of TCM,Hefei 230038,China; 2.The First affiliated Huspital of,Anhui College of TCM,Hefei 230031,China);Effect of Huangputongqiao Capsule on Leaning and Memory Ability, Cerebral NOS Activities in Rats with Vascular Dementia[J];中国中医基础医学杂志;2005-05
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 HE Wangsheng;YANG Wenming;DONG Ting;ZHOU Lei;HUANG Peng;DING Haopeng;LI Biao;The First Affiliated Hospital of Anhui University of Chinese Medicine;Anhui University of Chinese Medicine;;Exploration of the Intervention Mechanism of Naoluo Tong Granule on the Vascular Cognitive Impairment of Dementia Type Rat Models from Oxidative Stress[J];中医药临床杂志;2018-01
2 HUANG Liwu;CHEN Fei;LEI Yujun;WU Peng;LIN Fei;HUANG Xuanhua;FU Youxue;DOU Weihua;WANG Jinhua;CHEN Wei;DIAO Limei;LI Xiaodong;Department of Encephalopathy in Two Areas,The First Affiliated Hospitl of Guangxi University of Traitional Chinese Medicine;Guangxi University of Traditional Chinese Medicine;Ruikang Hospital Affiliated to Guangxi College of Traditional Chinese Medicine;;Influence of Yifei Xuanfei Jiangzhuo Formula on Expressions of iNOS and HO-1 in Hippocampus of Rats with Chronic Ischemic Vascular Dementia[J];辽宁中医杂志;2016-12
3 QIN Ya-li;ZHANG Jun-long;GUO Lei;HAN Cheng;CHEN Yan-qing;YU Hong;GUO Bin;Shandong University of Traditional Chinese Medicine;Shanxi University of Traditional Chinese Medicine;Shanxi Academy of Traditional Chinese Medicine;;Experimental Study on Oxidative Stress in the Rats of Senile Dementia with Syndrome of Stagnation of Blood and Cold and Phlegm Blockage Syndrome[J];世界中西医结合杂志;2014-05
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