Effect of Epimedium on Calcium and Phosphorus Metabolism in Degenerated Cervical Vertebral of Rats
ZHAO Kai,XU Sheng-chun(Dept.of Human Anatomy,Anhui Medical University,Anhui Hefei 230032,China)
Objective: To investigate the effect of epimedium on calcium and phosphorus metabolism in degenerated cervical vertebral of rats,to observe the inhibition effect of epimedium in bone of degenerated cervical vertebral and to explore the mechanism of epimedium for the prevention and treatment of cervical spondylosis.Methods: Thirty 6-month-old SD rats,male or female, weighing(220±20)g each,were randomly divided into two groups,model groups and sham group.The animal models were established by removing the muscle groups, the supraspinal and interspinal ligaments in the neck of rats.Cervical vertebrae X-ray were conducted 1 month and 3 months after model establishment.Three months later,the animal models were verified successfully according to X-ray result,and the model rats were divided into 2 groups randomly,epimedium group and saline group.Then epimedium group and saline group were administered with epimedium and saline respectively;sham group were administered with saline every day.The rats were killed to collect experimental samples after 2-month treatment,and then the blood samples were undergone for testing the contents of calcium, phosphorus,alkaline phosphatase and cervical bone specimens for testing calcium,phosphorus by using automatic biochemical analyzer respectively.Results:At the end of the experiment,the serum phosphate and alkaline phosphatase level in epimedium group were higher than those of other groups(P0.05),while there were no difference in their serum calcium levels(P0.05).The cervical vertebrae bone calcium and phosphate levels in saline group were lower than those of other groups(P0.01).The cervical vertebrae bone calcium and phosphate levels in epimedium group were higher than those of other groups(P0.01).Conclusion: Epimedium can improve the contents of calcium and phosphorus in degenerated cervical vertebral as well as prevent the degeneration of cervical bone.Epimedium can increase the activity of the serum alkaline phosphatase in degenerated cervical vertebrae,and it might inhibit the formation of osteophyte and delay cervical bone degeneration.
【Key Words】：
Degeneration of cervical vertebrae Calcium and phosphorus metabolism Epimedium
【CateGory Index】： R285
【CateGory Index】： R285
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