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《Journal of Anhui Traditional Chinese Medical College》 2008-04
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Effect of Active Components of Achyranthes Bidentata Blume on Contraction of Vascular Smooth Muscle

ZHENG Jie-zhen,ZHOU Da-xing,GU Jing,Li Fen-fen,CHEN Yu-ye,LOU Ying,WEI Si-rong(Zhejiang University of Chinese Medicine,Zhejiang Hangzhou 310053,China)  
Objective: To study the effects of active components(total saponins,total steroids and total alkaloids) of Achyranthes bidentata Blume on the contraction of vascular smooth muscle.Methods: Ex vivo specimen of rat aorta smooth muscle was employed.Firstly,The rat vascular smooth muscle was ex vivo treated with different concentration of active components of Achyranthes bidentata Blume,and its diastolic level was observed.Secondly,the norepinephrine(NE) induced vasoconstriction was antagonized by different concentration of active components of Achyranthes bidentata Blume,and its diastolic level was observed.Results: The total saponins of Achyranthes Bidentata Blume not only had significantly inhibitive effects on NE-induced vasoconstriction,but also had direct relaxation effect on vascular smooth muscle.Conclusion: The total saponins of Achyranthes bidentata Blume have the effects of direct vasodilatation and significant effect against α receptor.
【CateGory Index】: R285
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