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《Journal of Anhui Traditional Chinese Medical College》 2009-04
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Effect of Propolis Flavone on Life Spans in Drosophila and Its Protective Effects Against Injury by Free Radicals

ZHANG Chun-lei,YU Ying-jun(Jiamusi College,Heilongjiang University of Chinese Medicine,Heilongjiang Jiamusi 154007,China)  
Objective: To observe the influence of propolis flavone on life spans in drosophila and explore its mechanism in protecting against injury induced by free radicals.Methods:(1)Drosophila were randomly divided into five groups and cultivated in medium contained with 83,250 and 750 mg/kg propolis flavones and vitamin E,respectively.The number of dead drosophila was recorded every 24 hours,thus the average and maximum life span were calculated.At the same time the activity of superoxide dismutase(SOD) and the content of malonaldehyde(MDA) in drosophila homogenate were assayed.(2)Ninety mice were randomly divided into six groups.The aging rats induced by D-galactose were consecutively administered with 100,200,300 mg/kg propolis flavones and vitamin E during 30 days,respectively.One month later,The SOD activity and MDA content in brain homogenate were assayed.Results: Propolis flavone could significantly increase the SOD activity and decrease the MDA content in drosophila and mice,and prolong the average and maximum life span in drosophila.Conclusion: Propolis flavones inhibit or extenuate the peroxidation process by effectively eliminating free radicals,and possess an effect on delaying aging.
【CateGory Index】: R285
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