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《Journal of Anhui Traditional Chinese Medical College》 2012-02
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Effects of Acupuncturing Neiguan(PC6) and Shenmen(HT7) Acupoints on Noradrenaline in Paraventricular Nucleus and Serum of Hyperlipidemia Rats with Acute Myocardial Infarction

MA Yong,HU Wu-bin,WANG Ke-ming(School of Acupuncture,Moxibustion,Traumatology,and Orthopaedics,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China)  
Objective To observe the effects of acupuncturing "Neiguan"(PC6) and "Shenmen"(HT7)acupoints on noradrenaline(NE) levels in the paraventricular nucleus(PVN) and the serum of hyperlipidemia rats with acute myocardial infarction(AMI).Methods Of 100 SD rats with hypercholesterolemia,20 were randomly chosen into the sham control group,others were ligated in the left anterior descending coronary artery to induce AMI models.Those AMI rats were randomly divided into model control group,"Neiguan" group and "Shenmen" group.There were 20 rats in each group.The rats in "Neiguan" group and "Shenmen" group were treated with acupuncture at bilateral "Neiguan" acupoints and bilateral "Shenmen" acupoints for 5 days,respectively.The levels of NE in the PVN and the serum were assayed by enzyme linked immunosorbent assay and radio immunoassay.Results Compared with those in the sham control group,the NE levels in the PVN area in model control group were significantly decreased(P0.01),being contrary to significantly increased NE levels in the serum.Compared with those in the model control group,the NE levels in the PVN area in "Neiguan" group and in "Shenmen" group were significantly increased(P0.01),being contrary to significantly decreased NE levels in the serum(P0.01),but there was no significant difference in NE levels between "Neiguan" group and "Shenmen" group.Conclusion Acupuncture at "Neiguan" and "Shenmen" acupoints can increase NE levels in the PVN area and decrease NE levels in the serum of hyperlipidemia rats with AMI.
【Fund】: 安徽省自然科学基金项目(090413112)
【CateGory Index】: R245
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