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《Journal of Anhui Traditional Chinese Medical College》 2012-02
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Content Determination of Geniposide in Fructus Gardeniae and Baked Fructus Gardeniae Using Ultra Performance Liquid Chromatography

SHEN Chen,WU Hong,WU Huan,TENG Yue(School of Pharmacy,Anhui College of Traditional Chinese Medicine & Anhui Key Laboratory of Chinese Medicine Research and Development,Anhui Hefei 230031,China)  
Objective To establish an ultra performance liquid chromatography(UPLC) method for determining the contents of Geniposide in the medical materials of Fructus Gardeniae.Methods BEH C18 chromatographic column(1.7 μm,2.1 mm×100 mm) was employed,with acetonitrile-water(gradient elution) being mobile phase,wavelength being set at 238 nm,flow rate being 0.3 ml/min,and column temperature being 25 ℃.Results Within the range of 0.015 to 0.240 μg,Geniposide had a good linear relation to the peak area(y=0.056 2 x-0.075 6,r=0.999 1).The average recovery rate of Geniposide was 98.98% in Fructus Gardeniae(relative standard deviation was 0.40%,n=5) and 98.12% in baked Fructus Gardeniae(relative standard deviation was 0.47%,n=5).Conclusion UPLC can be used for determining Geniposide in medical materials of Fructus Gardeniae Because of its simplicity,rapidness,accuracy,and perfect reproducibility.
【Fund】: 国家自然科学基金(81073122);; 安徽省高等学校自然科学研究重点项目(KJ2009A045Z);; 安徽中医学院自然科学研究基金项目(2010zr010B)
【CateGory Index】: R284
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