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《Journal of Anhui Traditional Chinese Medical College》 2012-04
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Effects of Shumai Capsules on Angiotensin Ⅱ Induced Migration of Vascular Smooth Muscular Cells

YU Sheng1,DONG Jian-xun2,HUANG Min3(1.Department of Traditional Chinese Medicine,the First Hospital Affiliated to Anhui Medical University,Anhui Hefei 230022,China;2.Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100029,China;3.College of Life Sciences,Anhui University,Anhui Hefei 230039,China)  
Objective To observe the effects of Shumai Capsules(a traditional Chinese medicine recipe for invigorating spleen-and kidney-qi and activating blood circulation) and its component recipes on angiotensin II(AngII) induced migration of vascular smooth muscle cells(VSMCs).Methods VSMCs were cultured using tissue explants method.Ang Ⅱ 10-7mol/L was used as a stimulating factor.The medicinal sera were divided into overall Shumai Capsules group,activating blood circulation group,and invigorating spleen-and kidney-qi group.The migration distance was measured using micrometer.The expression of metalloproteinase-2(MMP-2) was assayed using immunohistochemistry.Results Compared with those in the AngⅡ group,the migration distance of VSMCs and the expression of MMP-2 were significantly decreased in the overall Shumai Capsules group and activating blood circulation group(P0.01).The migration distance of VSMCs in the overall Shumai Capsules group was significantly lower than that in the activating blood circulation group(P0.01).Conclusion Shumai Capsules can inhibit the migration of VSMCs by downregulating the expression of MMP-2.The effect of its overall recipe is better than that of its component recipes.
【Fund】: 北京市中医药科技发展基金项目(JJ2005-13)
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 2 Hits
1 DONG Jian-xun1,YU Sheng2,3,LU Guang-lin2,HAO Yu2,ZHANG Mei-ji2,ZHU Chao-jun1(1Beijing Hospital of Chinese Medicine,Capital Medical University,Beijing 100010,China;2Beijing University of Chinese Medicine,Bejing 100029,China;3The First Affi liated Hospital of Anhui Medical University,Hefei 230000,China);Influence in Shumai Capsule on Ang Ⅱinduced vascular smooth muscle dell proliferation and level of NO,SOD,MDA[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-05
2 YU Sheng1,DONG Jian-xun2,HAO Yu1,LU Guang-lin1,WANG Da-wei1(1 Beijing University of Chinese Medicine,Beijing 100029;2 Beijing Hospital of Chinese Medicine Affiliated to Capital University of Medical Sciences);Influence of Shumai Capsules on proliferation of VSMC induced by Ang Ⅱ and cell cycle[J];Journal of Beijing University of Traditional Chinese Medicine;2009-03
Chinese Journal Full-text Database 1 Hits
1 LIANG Jinning1,DONG Hongbo2,YU Hong3,SHAO Li1,LIANG Xuguo1(1.Shandong Province Yantai Yuhuangding Hospital,Yantai 264000,Shandong,China; 2.Shandong Province Yantai Mental Rehabilitation Hospital,Yantai 265200,Shandong,China; 3.Shandong Province Yantai Baishi Anorectal Hospital,Yantai 264001,Shandong,China);Effect of Angiotensin Ⅱ on MMPs in Vascular Smooth Muscle Cells and the Influences of Drugs on it[J];Journal of Practical Traditional Chinese Internal Medicine;2012-16
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Hong,GAO Xiu-mei,ZHANG Bo-li,et al (Tianjin University of TCM,Tianjin,300193,China);Influence of different component of danshen on the proliferation in vessel smooth muscle cell[J];Tianjin Journal of Traditional Chinese Medicine;2004-03
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