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Effects of Hedan Tablets Combined with Rosuvastatin Calcium on Carotid Intima-Media Thickness and Vascular Endothelial Function in Patients with Hyperlipidemia

FU Xiao-li;ZHAN Qian-li;MENG Fan-jun;YANG Ying-bo;DONG Xing;TIAN Xiao-yan;YIN Yu-hong;Second Department of Geriatrics,The First Central Hospital of Baoding;Second Department of Orthopaedics,The First Central Hospital of Baoding;  
Objective To observe the effects of Hedan Tablets combined with rosuvastatin calcium on ca-rotid intima-media thickness(IMT)and vascular endothelial function in patients with hyperlipidemia. Methods A total of 117patients with hyperlipidemia were randomly divided into study group(n=61)and control group(n=56).The control group received rosuvastatin calcium alone,while the study group received Hedan Tab-lets combined with rosuvastatin calcium.IMT,plaque area,serum lipids,nitric oxide(NO)level,and endothelin-1(ET-1)level were measured before and after 8weeks of treatment.Results Before treatment,there were no significant differences in serum lipids,IMT,plaque area,NO level,and ET-1level between the two groups(P0.05).After 8weeks of treatment,compared with the control group,the study group had significantly decreased triglyceride,total cholesterol,and low-density lipoprotein cholesterol levels(P 0.01),significantly increased high-density lipoprotein cholesterol and NO levels(P0.01),and signifi-cantly decreased ET-1level,IMT,and plaque area(P0.01).Conclusion Hedan Tablets combined with rosuvastatin calcium can significantly decrease serum lipids,improve vascular endothelial function,and de-crease IMT and plaque area in patients with hyperlipidemia.
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