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《JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE》 1997-04
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THE PROTECTIVE EFFECT OF ELECTROACUPUNCTURE AND MOXIBUSTION ON THE GASTRIC MUCOSAL DAMAGE AND THE RELATION WITH NITRIC OXIDE IN RATS

Pei Wenfen Xu Guansun Sun Yong Wang Yuefang Zhu Shunli Zhang Daoqin (Department of Physiology,Anhui College of TCM,Hefei 230038)   
Acute model of gastric mucosal damage induced by perfusion of the 70% ethanol to stomach was established.Gastric mucosal blood flow,transmucosal potential difference and gastric mucosal lesion index as indexes and the contents of nitric oxide (NO) in blood and gastric mucosal were detected.The protective effect of electroacupuncture(EA) and moxibustion(M) on the gastric mucosal damage in rats and the relation with nitric oxide were studied.The results obtained were as follows:EA and M may show the protective effect on the gastric mucosal damage in rats.Both precursor of NO L arginine(L arg) and donor of NO natrii Nitroprussidum(SNP) may also show the protective effect on the gastric mucosal damage in rats as well.But NO synthesis inhibitor N w nitro L arginine(L NNA) could not show the protective effect of the gastric mucosal damage in rats.Both by pretreament with L arg and SNP,the protective effectof EA and M on the gastric mucosal damage in rats were increased,but by pretreament with L NNA and L arg,the protective effect of EA and M on the gastric mucosal damage were reversed.Conclusion:the protective effect of EA and Mon the gastric mucosal damages in rats was mediated through actvation of L arg NO pathway.
【Fund】: 国家攀登计划
【CateGory Index】: R333.2
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