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《JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE》 1999-01
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THE PROTECTIVE EFFECT OF ELECTROACUPUNCTURE ON THE GASTRIC MUCOSAL DAMAGE INDUCED BY BRAIN ISCHEMIA IN RAT

Xu Guansun,Wang Jian,Shen Dekai,et al (Institute of acupuncture and meridian,Anhui college of TCM,Hefei,230038)  
Acute model of gastric mucosal damage induced by brain ischemia in rat was established.Cerebral blood flow(r CBF),gastric mucosal blood flow(GMBF),gastric mucosal lesion index(LI),the contents of nitric oxide(NO)in blood,gastric mucosal and cortex tissue were detected.The protective effect of electroacupuncture(EA) on the gastric mucosal damage during cerebral ischemia were studied.The results were follows:EA may show the protective effect on the gastric mucosal damage induced by brain ischemia after 1h in rat.By pretreatment with the precursor of NO-L arginine(L arg)may also show the gastric protective effect of EA,but by pretreatment with NO synthesis inhibitor N ω nitro L arginine(L NNA)could not show the gastric protective effect of EA in rat.It is suggested that the protective effect of EA on the gastric mucosal damage induced by brain ischemia in rat was mediated through activation of L arg-NO pathway.
【Fund】: 国家攀登计划和安徽省教委资助
【CateGory Index】: R246.6
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