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《JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE》 1999-02
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ACUTE AND CHRONIC TOXICITY TEST OF TEA POLYPHENOLS

Song Xiaoge,Yuang Jing,Tang Zhaoliang,et al ( Anhui College of TCM,Hefei 230038 )  
Objective:The study was to observe the acute and chronic toxicity of Tea Polyphenols(TP).Methods:the mice were divided into five groups and TP was given orally for 7 days.The method of Bliss was used to determine the LD 50 of the TP.The rats was divided into control group,TP high dosage group,TP middle dosage group and low dosage group(0.4,0.6,0.8g/kg·d -1 ) to observe the chronic toxicity.Result:The LD 50 of TP is 2.499g/kg.The rats have showed no toxicity reaction in weight,blood,the internal organs,liver and kidneys function after the using of the drug.Conclusion:The TP has low toxicity,the dosage of 0.8g/kg.d -1 in rat is equivalent to 100 times of the dosage used in clinic for an adult.It indicates that the clinical using of TP is safe.
【Fund】: 安徽省自然科学基金
【CateGory Index】: R965.3
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