THE DETOXICATION OF MECHLORETHAMINE HYDROCHLORIDE BY 6, 7-DIMETHOXYCOUMARIN
WAN Yao-de XU Jia-hong(Sichuan Institute of Chinese Materia Medica)
6, 7-Dimethoxycoumarin (ip. or po.) can increase remarkably the half-monthsurvival rate of rats and mice intoxicated by mechlorethamineHCL(HNZ), accelerate the recovery of the body weight of intoxicated rats , It can increase also the LD50 value of HN2 in rats, the dose reduction factor (DRF) was 1.333. At the same time, dimethoxycoumarin did not reduce the antitumor(S180, V14) effect of HN2- However, it provided good protection against the toxicityof cyclophosphamide, but not to the toxicity of camptothecine, 5-fluorouracil methotrexate. vincris-tine and cantharidin.