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《Chinese Journal of Cancer》 1989-06
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THE EFFECTS OF METHYLMERPHALAN(AT-1420) ON THE CYTOKINETICS OF EHRLICH ASCITIC TUMOR CELLS AND ON THE DNA SYNTHESIS OF HeLa CELLS

X IAN Li-jian PAN Qi-chao(Cancer Institute- Sun Yat-sen University of Medical Sciences, Guangzhou 510060)  
In our previous studies it was proved that Methylmerphalan (AT-1420) possessed significant antitumor activity against some kinds of transplantable tumors in mice without accumulating toxicity. In this paper it was further shown that AT-1420 strongly inhibited EAC cells in logarithmic growth phase- Direct cytotoxicity was found in cultivated HeLa cells. The 3 H-TdR incorporation into HeLa cells was inhibited by 43-66% under the conce-tration of 10μg/ml of AT-1420, by 23- 26% under 50 μ g/ml. In the cytokinetic studies using computerized microspectrophotometer it was shown that EAC cells accumulated in G 1 phase and was retarded entering into S phase 4 hours after administration of AT-1420. . Many G 1 phase cells and considerable part of the cells with low DNA content were found until 24 hours after administration of AT-1420. It was suggested that AT-1420 is not suitable for use with S Phase specific agents (MTX, AraC and etc) simultaneously, in order to avoid the lowering of therapeutic effect caused by self_limiting effect.
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