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《Chinese Journal of Cancer》 1992-01
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ADDITIVE EFFECT OF RETINOIC ACID AND SELENITE ON THE INHIBIT ON OF CELL GROWTH AND DNA SYNT- HESIS OF HUMAN HEPATOCARCINOMA CELL LINE

QIN Suo-fu LI Zhi-wen ZHA Xi-liang CHEN Hui-li (Department of Biochemietry, Shanghai Medical University, Shanghai. 200032)  
The effects of retinoic acid and selenite on the growth and DNA synthesis of human hepatocarcinoma cell line SMMC-7721 were studed. It, was found that retinoic acid (RA, 1-10μ mol/L) and selenite (Se 2.5-10μmol /L) inhibited cell growth markedly and their inhibitions were gradually saturated as the concentration of RA or Se were increased to a definite level When 1μ mol/L RA and 2.5μmol /L Se were used together, an additive inhibition on the cell growth or 3H-TdR incorporation rate into SMMC-7721 cell was found. The inhibition of 1μmol/L RA was similar to that of 2.5μ mol/L selenite on the cell growth and 3H-TdR incorporation when each of them was used alone.
【Key Words】： Human hepatocarcinoma cell line Sodium selenite Retinoic acid 3H-TdR incorporation rate. Additive effect.
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