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《Chinese Journal of Cancer》 1992-02
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THE EFFECTS OF STRESS ON TUMOR METASTASIS AND ITS IMMUNE MECHANISM

ZHOU Jim-fang YAO Li-ren(Department of pathophysiology, Anhui medical university Anhui Hefei. 230022)  
In order to investigate the effects of stress on tumor metastasis and its immune mechanism, electric stimulation with gradually increased intensity was given to female C57 BL mice for 7 consecutive days. At 8th day, mice were i.v. inoculated with 7.5×10 4/0.2mI/mouse B16 melonoma cells and electric stimulation was given for another 3 days. At 18th day after tumor cell inoculation, mice were sacrificed. The results were as follows: (1)It was found that the numbers of metastasis of stressed mice (median 134) were significantly higher than those in control mice (median 63)(P0.01) ; (2) The responses of cell immunity (DTH response to SRBC, proliferative response of T lymphocytes to ConA and carbon clearance) and humoral immunity (PFC formation) in stressed mice were markedly decreased than those in control mice. Furthermore, the adrenal gl-ande were heavier and thy muses and spleens lighter in stressed mice than those in control mice. The results shaved that stresses suppress immune responses and promote tumor metastasis. It is suggested that stresses such as serious life events promote tumor metastasis and have harmful influences on tumor prognosis, so psychical factors can not be neglected in clinical cancer therapy .
【Fund】: 国家自然科学基金
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