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《Chinese Journal of Cancer》 1999-02
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Enhancement of HLA-DR expression in human hepatocellular carcinoma by interferon and its significance

YANG Lian-jnn; SUI Yan-fang; CHEN Zhi-nan (Department of pathology, Fourth Military Medical University, Xi' an 710032, China)  
Object: To require into the regulative effect of interferon (IFN) on HLA-DR expression in human heaptocellular carcinoma (HCC). Methods: The expression of HLA-DR in 4 HCC cell lines, HHCC, SMMC-7721, BEL-7402,HCC-9204 and a normal liver cell line QZG was detected with immunohistochemical ABC and ELISA methods before and after stimulated by different doses of IFN-γ or IFN-α. ResultS: Only a little part of SMMC-7721 cells expressed HLA-DR before stimulation by IFN-γ or IFN-α, and the others were HLA-DR negative; HLA-DR expression enhanced in all of the 5 cell lines after stimulation, and was correlated with the dose of IFN, QZG was less obvious than HCC cells, the effect of IFN-γ was obvious than IFN-α. Conclusion: IFN can induce HLA-DR expression in HCC cells and make self-immunological adjustment in HCC on some extent.
【Fund】: 国家863课题!10-09-01-02;;国家自然科学基金!39770827
【CateGory Index】: R735.7
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