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The loss of heterozygosity and microsatellite DNA instability of esophageal carcinomas in multiple tumor suppressor genes polymorphous sites

Wu Kong ming,WANG Ming rong, WANG Rui lin, et al.The First Affiliated Hospital of Henan Medical University,Zhengzhou 450052,P.R.China  
Objective:To study the deletion frequency of tumor suppressor genes p53,p16,Rb, DCC,APC,FHIT, PTEN in esophageal carcinoma(EC) and their relationship to clinic pathological characteristics.Method:Using PCR silver staining technique,the loss of heterozygosity(LOH) and microsatellite instability(MSI) among 14 microsatellite DNA polymorphic markers were examined in 36 matched human esophageal cancers and adjacent normal mucosal tissues. Rsults:High frequency of LOH ( 25%) was found in D17S261,D9S162,D9S171,IFNA and D13S170, which were respectively linked to p53, p16 and Rb genes.Eighty six percent (86%) of patients had 2 or more aberrant sites, the tumors of pTNM Ⅲshowed more abnormal sites than those of pTNM Ⅱ.Conclusion:Multiple microsatellite DNA abnormality in the same tissues suggested that more than one suppressor gene was deleted during the carcinogeneses of esophageal epithelia.
【Fund】: 863 重大项目基金;九五攻关项目基金;河南省重大项目基金
【CateGory Index】: R735.1
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