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《CHINESE JOURNAL OF CANCER》 1999-04
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The loss of heterozygosity and microsatellite DNA instability of esophageal carcinomas in multiple tumor suppressor genes polymorphous sites

Wu Kong ming,WANG Ming rong, WANG Rui lin, et al.The First Affiliated Hospital of Henan Medical University,Zhengzhou 450052,P.R.China  
Objective:To study the deletion frequency of tumor suppressor genes p53,p16,Rb, DCC,APC,FHIT, PTEN in esophageal carcinoma(EC) and their relationship to clinic pathological characteristics.Method:Using PCR silver staining technique,the loss of heterozygosity(LOH) and microsatellite instability(MSI) among 14 microsatellite DNA polymorphic markers were examined in 36 matched human esophageal cancers and adjacent normal mucosal tissues. Rsults:High frequency of LOH ( 25%) was found in D17S261,D9S162,D9S171,IFNA and D13S170, which were respectively linked to p53, p16 and Rb genes.Eighty six percent (86%) of patients had 2 or more aberrant sites, the tumors of pTNM Ⅲshowed more abnormal sites than those of pTNM Ⅱ.Conclusion:Multiple microsatellite DNA abnormality in the same tissues suggested that more than one suppressor gene was deleted during the carcinogeneses of esophageal epithelia.
【Fund】: 863 重大项目基金;九五攻关项目基金;河南省重大项目基金
【CateGory Index】: R735.1
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【References】
Chinese Journal Full-text Database 1 Hits
1 LENG Wei-chun,LIU Jun-bao,CHEN Feng.(Depatment of Gynecology,Chine-Japan Union Hospital of Jilin University,Changchun 130033,China);Study for microsatellite instability of ovarian cancer[J];Chinese Journal of Laboratory Diagnosis;2010-02
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Weidong;Wand Liang;Wang Xiuqin;et al.(Department of Cell Bilology,Cancer Institute,PUMC,CAMS,Beijing 100021);CHROMOSOME LOCI SPECIFIC LOSS OF HETEROZYGOSITY AND MICROSATELLITE INSTABILITY IN ESOPHAGEAL CANCER TISSUES[J];CHINESE JOURNAL OF MEDICAL CENETICS;1996-04
2 Jin Shunqian, Peng Qiong, Lu Shixin, et al. Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021;Deletion of MTS1/p16 gene in human esophageal carcinoma[J];CHINESE JOURNAL OF ONCOLOGY;1998-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Xu Chun Lei, Qian Xin Lai, Zhou Xiao Shan, Zhao Qing Zheng, Li Yan Chun Cancer Institute, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing,100021, P.R.China;Expression of HPV16-E6 and E7 Oncoproteins in Squamous Cell Carcinoma Tissues of Esophageal Cancer and Non-cancer Tissues[J];Chinese Journal of Cancer;2004-02
2 YAO Han-Qing1,2,HE Shun1,WU Yu-Peng2,WANG Xiao-Chun2,HAN Ya-Ling2,XU Xin2,CAI Yan2,WANG Gui-Qi1,WANG Ming-Rong21.Department of Endoscopy,Cancer Institute / Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100021,P.R.China 2.State Key Laboratory of Molecular Oncology,Cancer Institute / Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100021,P.R.China;Application of Multicolor Fluorescence In situ Hybridization to Early Diagnosis of Esophageal Squamous Cell Carcinoma[J];Chinese Journal of Cancer;2008-11
3 YAN Kun, WANG Ming rong,FANG Dian chun,et al. (Department of Cardiothoracic Surgery,Southwest Hospital,the Third Military Medical University,Chongqing 400038,China);MSI analysis of microsatellite locia BAT-26 at 45 esophageal cancer[J];Chongqing Medical Journal;2004-02
4 Zhang Huizhong,Li Haigang,Shen Ximing, et al.(Depeartment of Cardiothoracic Surgery, Sun Yat - sen Memorial Hospital,Sun Yat-Sen University ofMedical Sciences,Guangzhou 510120);Significance of p16 protein expression in human esophageal squamous cell carcinoma[J];GUANGDONG MEDICAL JOURNAL;1999-05
5 Wang Shujun~1,Zhang Jian~1,Qiu Songliang~1,Yang Guanrui~1,Zhang Yabing~1,Qiu Yibing~1,Zhang Juzhen~1,Sun Yu~1,Yang Jing~1,Xue Lexun~2,Zhao Liqun~1 (1.Department of Tumor Pathology,Henan Institute of Medical Science;2.Laboratory of Cell Biology,Zhengzhou University,Zhengzhou 450052,China);A Study of Shh and Ptch Expressions in Esophageal Squamous Cell Carcinoma[J];Journal of Basic and Clinical Oncology;2006-03
6 YAN Ming 1) ,CAO Wei 2) ,CHANG Fubao 3) ,ZHANG Qian 1) 1)Department of Physiology,Henan Medical University,Zhengzhou 450052 2)Department of Pathology,Xinxiang Medical College,Xinxiang 453003 3)Linzhou Esophageal Cancer Hospital of Hena;Relationship between single strain conformation polymorphism alteration of p53 and the survival rate in the patients with esophageal squamous cell carcinoma[J];Journa of Henan Medical University;2000-06
7 Wang Dong, Su Changqing, Ye Yukun, et al. Nanjing 81 Hospital, Nanjing 210002;Deletion of MTS1/p16 gene in human lung cancers[J];Chinese Clinical Oncology;2000-03
8 Zhang Ping, Wu Qingquan . Department of Oncological Surgery, Huaiyin First Hopital, Huaiyin 223000;Relationship between the deletion of the MTS1/p16 gene and the biological character of gastric cancer[J];Chinese Clinical Oncology;2001-01
9 Peng Hui, Yang Guanghua, Bu Hong, Guo Lixin, Wang Hua (Department of Pathology, West China Hospital, Sichuan University,Chengdu 610041);Microsatellite instabilities on chromosome 3p in leiomyosarcoma of soft tissue and its clinical significance[J];Chinese Journal of Clinical and Experimental Pathology;2004-03
10 Ren Zhanping; Shi Zhe; Chen Weilin; et al(Dept of Pathol,The First People's Hospital of Liuzhou,Guangxi 545001);Expression of HPV16,18 E_6 protein and p21ras,p53 in the carcinoma of esophagus[J];CHINESE JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOG;1996-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 DUAN Xiao ming1, ZHANG Gui ying1, CHEN Zhu chu2* , et al. 1. Department of Gastroenterology, Affiliated Xiangya Hospital, Hunan Medical University,Changsha 410008, P.R.China 2. Laboratory of Tumor Cell Biology, Cancer Research Institute, Hunan Me;Abnormal expression of the FHIT gene in human primary colorectal cancer and colorectal cancer cell lines[J];CHINESE JOURNAL OF CANCER;2000-09
2 ZHAO Po*, LI Xiao ying, CHEN Le zhengDepartment of Pathology,General Hospital of People's Liberation Army,Beijing 100853,P.R.China;Loss of Fragile Histidine Triad Expression and Metastasis in Breast Cancer[J];Chinese Journal of Cancer;2002-06
3 PU Yi ping,WU Jia lian,CAO Qian, et al (Department of ENT, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010);Influence of antisense oligodeoxynucleotide targeting against telomerase on expression of carcinoma gene of laryngeal carcinoma cells[J];Chongqing Medical Journal;2002-01
4 Xu Xianfa, Li Li, Zhang Jianjun, Gao Yanning, Zhang Ruihua, Tang Pingzhang, Cheng ShujunFrom the Department of Otolaryngology\|Head and Neck Surgery, Affiliated Beijing Chaoyang Hospital of Capital University of Medical Sciences, Beijing 100020 ];Loss of heterozygosity of tumor suppressor genes on chromosome 3p in laryngeal squamous cell carcinoma by microsatellite analysis[J];;2002-04
5 CHEN Guoan , LIU Tianju, SUN Yan,LI Shende, Yang Dechang. The Second Affiliated Hospital, Xi'an Medical University, Xi'an 710004, P.R.China;Mismatch repair gene mRNA expression in lung cancer tissues[J];CHINESE JOURNAL OF LUNG CANCER;2000-01
6 ZHOU Qinghua, CHEN Jun, QIN Yang, SUN Zhilin, LIU Lunxu, SUN Zefang, CHE Guowei, LI Lu, Qin Jianjun, GONG Youling. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R;A study on the allelic deletion and mutation of FHIT gene in human non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2001-01
7 ZHANG Qinxian, DU Peng, DING Yi, LE Xiaoping, JIN Hui Molecular Cell Biology Research Center, Henan Medical University;Henan Key Laboratory of Molecular Medicine, Zhengzhou 450052;Study on microsatellite DNA instability in p16 gene of gastric cancer tissues[J];Journa of Henan Medical University;2001-04
8 YIN Detao, WANG Qingzhao, LU Xiubo, QIU Xinguang Department of General Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;Expressions of E-cadherin and CD44v6 in papillary thyroid carcinoma[J];Journa of Henan Medical University;2002-04
9 GAO Yongshun, WANG Qingzhao, LU Xiubo, QIU Xinguang, YIN Detao Department of General Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;Expressions of CD57 and EMA in follicular thyroid neoplasm[J];Journa of Henan Medical University;2002-04
10 Shen Jie,Xie Juexing,Zhang Weizhong,et al.Department of Surgery,First People's Hospital of Taizhou,Taizhou,Zhejiang 318020,China;Hereditary instability of BRCA1 gene at locus D17S855 in hepatocellular carcinoma in Chinese[J];Medical Journal of Chinese People's Liberation Army;2008-09
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